Chipysheva T A, Ermilova V D, Vishnevskaia Ia V, Vasil'ev Iu M
Arkh Patol. 2005 Nov-Dec;67(6):24-7.
An immunomorphological study of 30 breast carcinomas was conducted. In accordance with the histological characteristics they had been previously diagnosed as lobular infiltrative carcinomas (LIC). We have studied E-cadherin cell-cell adhesion molecules and also epithelial markers and basement membranes. We have analyzed the cryostate and paraffin sections of in situ structures, invasion components and metastases. E-cadherin staining was negative, positive or mixed. The E-cadherin negative group consisted of 17 carcinomas of classic LIC accompanied with dyshesive invasion. The E-cadherin positive group consisted of 6 carcinomas. According to our results this diagnosis was changed to ductal infiltrative carcinoma. The E-cadherin mixed group consisted of 7 special type carcinomas with double lobular-ductal differentiation, which had in situ structures of negative or positive cells. In these cases in situ structures consisting of both E-cadherin negative and positive parts were also observed. It is shown that E-cadherin expression can be used in doubtful cases in order to differentiate between the lobular and ductal forms of breast carcinoma.
对30例乳腺癌进行了免疫形态学研究。根据组织学特征，这些病例先前被诊断为小叶浸润性癌（LIC）。我们研究了E-钙黏蛋白细胞间黏附分子以及上皮标志物和基底膜。我们分析了原位结构、浸润成分和转移灶的冷冻切片和石蜡切片。E-钙黏蛋白染色呈阴性、阳性或混合性。E-钙黏蛋白阴性组由17例伴有松散浸润的经典LIC癌组成。E-钙黏蛋白阳性组由6例癌组成。根据我们的结果，这一诊断改为导管浸润性癌。E-钙黏蛋白混合组由7例具有双小叶-导管分化的特殊类型癌组成，其原位结构有阴性或阳性细胞。在这些病例中，也观察到了由E-钙黏蛋白阴性和阳性部分组成的原位结构。结果表明，E-钙黏蛋白表达可用于疑难病例，以区分乳腺癌的小叶型和导管型。
