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1
Comparative characterization of Aedes 3-hydroxykynurenine transaminase/alanine glyoxylate transaminase and Drosophila serine pyruvate aminotransferase.埃及伊蚊3-羟基犬尿氨酸转氨酶/丙氨酸乙醛酸转氨酶与果蝇丝氨酸丙酮酸转氨酶的比较特征分析
FEBS Lett. 2002 Sep 11;527(1-3):199-204. doi: 10.1016/s0014-5793(02)03229-5.
2
Evolution of two alanine glyoxylate aminotransferases in mosquito.蚊子体内两种丙氨酸乙醛酸氨基转移酶的进化
Biochem J. 2006 Aug 1;397(3):473-81. doi: 10.1042/BJ20060469.
3
3-Hydroxykynurenine transaminase identity with alanine glyoxylate transaminase. A probable detoxification protein in Aedes aegypti.3-羟基犬尿氨酸转氨酶与丙氨酸乙醛酸转氨酶的同一性。埃及伊蚊中一种可能的解毒蛋白。
J Biol Chem. 2002 May 3;277(18):15781-7. doi: 10.1074/jbc.M201202200. Epub 2002 Mar 5.
4
Crystal structures of Aedes aegypti alanine glyoxylate aminotransferase.埃及伊蚊丙氨酸乙醛酸转氨酶的晶体结构
J Biol Chem. 2006 Dec 1;281(48):37175-82. doi: 10.1074/jbc.M607032200. Epub 2006 Sep 21.
5
Crystallization and characterization of human liver kynurenine--glyoxylate aminotransferase. Identity with alanine--glyoxylate aminotransferase and serine--pyruvate aminotransferase.人肝脏犬尿氨酸-乙醛酸氨基转移酶的结晶与特性。与丙氨酸-乙醛酸氨基转移酶和丝氨酸-丙酮酸氨基转移酶的同一性。
Biochem J. 1980 Sep 1;189(3):581-90. doi: 10.1042/bj1890581.
6
Identification and biochemical characterization of the Anopheles gambiae 3-hydroxykynurenine transaminase.冈比亚按蚊3-羟基犬尿氨酸转氨酶的鉴定及生化特性研究
FEBS J. 2005 Nov;272(21):5653-62. doi: 10.1111/j.1742-4658.2005.04961.x.
7
Human wild-type alanine:glyoxylate aminotransferase and its naturally occurring G82E variant: functional properties and physiological implications.人类野生型丙氨酸：乙醛酸转氨酶及其天然存在的G82E变体：功能特性及生理意义。
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Biochemical Evolution of a Potent Target of Mosquito Larvicide, 3-Hydroxykynurenine Transaminase.昆虫生长调节剂 3-羟基犬尿氨酸转氨酶的生物化学进化。
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Discovery of 1,2,4-oxadiazole derivatives as a novel class of noncompetitive inhibitors of 3-hydroxykynurenine transaminase (HKT) from Aedes aegypti.发现 1,2,4-噁二唑衍生物是一种新型的非竞争性 3-羟基犬尿氨酸转氨酶（HKT）抑制剂，来自埃及伊蚊。
Bioorg Med Chem. 2020 Jan 15;28(2):115252. doi: 10.1016/j.bmc.2019.115252. Epub 2019 Dec 9.
10
Oxalate synthesis in mammals: properties and subcellular distribution of serine:pyruvate/alanine:glyoxylate aminotransferase in the liver.哺乳动物中草酸盐的合成：肝脏中丝氨酸：丙酮酸/丙氨酸：乙醛酸转氨酶的特性及亚细胞分布
Mol Urol. 2000 Winter;4(4):333-40.

引用本文的文献

1
Biochemical Evolution of a Potent Target of Mosquito Larvicide, 3-Hydroxykynurenine Transaminase.昆虫生长调节剂 3-羟基犬尿氨酸转氨酶的生物化学进化。
Molecules. 2022 Aug 2;27(15):4929. doi: 10.3390/molecules27154929.
2
A second generation of 1,2,4-oxadiazole derivatives with enhanced solubility for inhibition of 3-hydroxykynurenine transaminase (HKT) from .第二代具有增强溶解性的1,2,4-恶二唑衍生物，用于抑制来自……的3-羟基犬尿氨酸转氨酶（HKT） 。
RSC Med Chem. 2020 Dec 9;12(2):222-236. doi: 10.1039/d0md00305k. eCollection 2021 Mar 4.
3
Fast and low-cost evaluation of hydroxykynurenine activity.羟基犬尿氨酸活性的快速低成本评估
MethodsX. 2020 Jul 2;7:100982. doi: 10.1016/j.mex.2020.100982. eCollection 2020.
4
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Front Mol Biosci. 2018 Jul 26;5:66. doi: 10.3389/fmolb.2018.00066. eCollection 2018.
5
Detoxification and stress response genes expressed in a western North American bumble bee, Bombus huntii (Hymenoptera: Apidae).在北美西部的一种熊蜂——亨氏熊蜂（膜翅目：蜜蜂科）中表达的解毒和应激反应基因。
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6
Biochemical mechanisms leading to tryptophan 2,3-dioxygenase activation.导致色氨酸2,3-双加氧酶激活的生化机制。
Arch Insect Biochem Physiol. 2007 Feb;64(2):74-87. doi: 10.1002/arch.20159.
7
The tryptophan oxidation pathway in mosquitoes with emphasis on xanthurenic acid biosynthesis.蚊子中的色氨酸氧化途径，重点是黄尿酸的生物合成。
J Insect Physiol. 2007 Mar;53(3):254-63. doi: 10.1016/j.jinsphys.2006.09.004. Epub 2006 Sep 17.
8
Evolution of two alanine glyoxylate aminotransferases in mosquito.蚊子体内两种丙氨酸乙醛酸氨基转移酶的进化
Biochem J. 2006 Aug 1;397(3):473-81. doi: 10.1042/BJ20060469.
9
Crystal structure of the Anopheles gambiae 3-hydroxykynurenine transaminase.冈比亚按蚊3-羟基犬尿氨酸转氨酶的晶体结构
Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5711-6. doi: 10.1073/pnas.0510233103. Epub 2006 Apr 3.
10
Cysteine and keto acids modulate mosquito kynurenine aminotransferase catalyzed kynurenic acid production.半胱氨酸和酮酸调节蚊子犬尿氨酸转氨酶催化的犬尿喹啉酸生成。
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本文引用的文献

1
3-Hydroxykynurenine transaminase identity with alanine glyoxylate transaminase. A probable detoxification protein in Aedes aegypti.3-羟基犬尿氨酸转氨酶与丙氨酸乙醛酸转氨酶的同一性。埃及伊蚊中一种可能的解毒蛋白。
J Biol Chem. 2002 May 3;277(18):15781-7. doi: 10.1074/jbc.M201202200. Epub 2002 Mar 5.
2
Kynurenine aminotransferase and glutamine transaminase K of Escherichia coli: identity with aspartate aminotransferase.大肠杆菌的犬尿氨酸转氨酶和谷氨酰胺转氨酶K：与天冬氨酸转氨酶相同。
Biochem J. 2001 Dec 15;360(Pt 3):617-23. doi: 10.1042/0264-6021:3600617.
3
Molecular basis for the dual mitochondrial and cytosolic localization of alanine:glyoxylate aminotransferase in amphibian liver cells.两栖类动物肝细胞中丙氨酸：乙醛酸转氨酶线粒体和胞质双重定位的分子基础。
J Biol Chem. 2002 Jan 18;277(3):2336-44. doi: 10.1074/jbc.M107047200. Epub 2001 Nov 2.
4
Peroxisomal alanine : glyoxylate aminotransferase (AGT1) is a photorespiratory enzyme with multiple substrates in Arabidopsis thaliana.过氧化物酶体丙氨酸：乙醛酸氨基转移酶（AGT1）是拟南芥中一种具有多种底物的光呼吸酶。
Plant J. 2001 Mar;25(5):487-98. doi: 10.1046/j.1365-313x.2001.00961.x.
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HPLC method for analysis of free amino acids in fish using o-phthaldialdehyde precolumn derivatization.采用邻苯二甲醛柱前衍生化的高效液相色谱法分析鱼肉中的游离氨基酸。
J Agric Food Chem. 1999 Dec;47(12):5100-7. doi: 10.1021/jf990032+.
6
Transamination of 3-hydroxykynurenine to produce xanthurenic acid: a major branch pathway of tryptophan metabolism in the mosquito, Aedes aegypti, during larval development.3-羟基犬尿氨酸转氨生成黄尿酸：埃及伊蚊幼虫发育过程中色氨酸代谢的一条主要分支途径。
Insect Biochem Mol Biol. 1997 Oct;27(10):859-67. doi: 10.1016/s0965-1748(97)00068-4.
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Variable peroxisomal and mitochondrial targeting of alanine: glyoxylate aminotransferase in mammalian evolution and disease.丙氨酸：乙醛酸氨基转移酶在哺乳动物进化和疾病中的过氧化物酶体和线粒体靶向可变
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Targeting of alanine: glyoxylate aminotransferase in normal individuals and its mistargeting in patients with primary hyperoxaluria type 1.
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Cloning of rat and human kynurenine aminotransferase.
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Cloning and functional expression of a soluble form of kynurenine/alpha-aminoadipate aminotransferase from rat kidney.大鼠肾脏中犬尿氨酸/α-氨基己二酸转氨酶可溶性形式的克隆及功能表达
J Biol Chem. 1995 Dec 8;270(49):29330-5. doi: 10.1074/jbc.270.49.29330.

埃及伊蚊3-羟基犬尿氨酸转氨酶/丙氨酸乙醛酸转氨酶与果蝇丝氨酸丙酮酸转氨酶的比较特征分析

Comparative characterization of Aedes 3-hydroxykynurenine transaminase/alanine glyoxylate transaminase and Drosophila serine pyruvate aminotransferase.

作者信息

Han Qian, Li Jianyong

机构信息

Department of Pathobiology, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, IL 61802, USA.

出版信息

FEBS Lett. 2002 Sep 11;527(1-3):199-204. doi: 10.1016/s0014-5793(02)03229-5.

DOI:10.1016/s0014-5793(02)03229-5
PMID:12220660
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2857927/
Abstract

This study describes the comparative analysis of two insect recombinant aminotransferases, Aedes aegypti 3-hydroxykynurenine (3-HK) transaminase/alanine glyoxylate aminotransferase (Ae-HKT/AGT) and Drosophila melanogaster serine pyruvate aminotransferase (Dm-Spat), which share 52% identity in their amino acid sequences. Both enzymes showed AGT activity. In addition, Ae-HKT/AGT is also able to catalyze the transamination of 3-HK or kynurenine with glyoxylate, pyruvate or oxaloacetate as the amino acceptor. Kinetic analysis and other data suggest that Ae-HKT/AGT plays a critical role in mosquito tryptophan catabolism by detoxifying 3-HK and that Dm-Spat is primarily involved in glyoxylate detoxification.

摘要

本研究描述了两种昆虫重组氨基转移酶的比较分析，即埃及伊蚊3-羟基犬尿氨酸（3-HK）转氨酶/丙氨酸乙醛酸转氨酶（Ae-HKT/AGT）和黑腹果蝇丝氨酸丙酮酸转氨酶（Dm-Spat），它们的氨基酸序列有52%的同源性。两种酶均表现出AGT活性。此外，Ae-HKT/AGT还能够催化以乙醛酸、丙酮酸或草酰乙酸作为氨基受体时3-HK或犬尿氨酸的转氨作用。动力学分析和其他数据表明，Ae-HKT/AGT通过解毒3-HK在蚊子色氨酸分解代谢中起关键作用，而Dm-Spat主要参与乙醛酸解毒。