Zhang Kehong, Davids Eugen, Tarazi Frank I, Baldessarini Ross J
Mailman Research Center, McLean Division of Massachusetts General Hospital, 115 Mill Street, Belmont, MA 02478, USA.
Brain Res Dev Brain Res. 2002 Aug 30;137(2):135-8. doi: 10.1016/s0165-3806(02)00436-4.
We examined serotonin (5-HT) transporters in rat forebrain using quantitative autoradiography at three distinct developmental stages after neonatal 6-hydroxydopamine lesions. The lesions substantially increased 5-HT transporter binding in both caudate-putamen and nucleus accumbens, but not cerebral cortex. The effects reached maximal levels as early as postnatal day (PD) 24, and were sustained until early adulthood. Behavioral analyses indicated that neonatal lesions resulted in motor hyperactivity on PD 24, but not on PD 36 or 59. These findings suggest that excess 5-HT transporters reflect serotonin hyperinnervation reported to occur in lesioned rats, and may modulate motor hyperactivity.
我们在新生大鼠接受6-羟基多巴胺损伤后的三个不同发育阶段，使用定量放射自显影技术检测了大鼠前脑血清素（5-羟色胺，5-HT）转运体。损伤使尾状核-壳核及伏隔核中的5-HT转运体结合显著增加，但大脑皮层未出现此现象。这些影响早在出生后第（PD）24天就达到最高水平，并持续至成年早期。行为分析表明，新生期损伤在PD 24时导致运动亢进，但在PD 36或59时未出现。这些发现提示，过量的5-HT转运体反映了在损伤大鼠中报道的血清素超神经支配现象，并且可能调节运动亢进。
