Dehne Marius G, Sablotzki Armin, Hoffmann Andreas, Mühling Jörg, Dietrich Friedrich E, Hempelmann Gunter
Department of Anaesthesiology and Intensive Care Medicine, Justus-Liebig-University of Giessen, Rudolf-Buchheim-Strasse 7, Germany.
Burns. 2002 Sep;28(6):535-42. doi: 10.1016/s0305-4179(02)00050-5.
To determine the acute immunologic reaction, mediated by cytokines, interleukines (ILs) and growth factors and the susceptibility to infections and sepsis after severe burn injury a prospective, single unit, longitudinal study of acute phase reactants and mediators who performed. After approval by the ethics committee of our hospital, we investigated the plasma concentrations of IL-2, -6, -8, -10, and -13, the soluble IL-2 receptor (sIL-2R), and the acute phase proteins procalcitonin (PCT) and C-reactive protein (CRP) at admission and every 3 days in 24 patients over a time course of 28 days after thermal injury and categorized by percent burn: < or =30% (group 1; n=12) and >30% (group 2; n=12). Shortly after burn injury we found higher concentrations of IL-2, -6, -10 and PCT in those patients >30% TBSA. During the study period, we found significant higher levels of acute phase proteins, IL-6 and -8 in patients >30% TBSA. The incidence of SIRS and MODS was three times increased in patients >30% TBSA. Our results show different patterns of cytokines and acute phase proteins in patients with different burned surface areas over a long time and continuous monitoring of a more distinct inflammatory response in these patients.
为了确定由细胞因子、白细胞介素（ILs）和生长因子介导的急性免疫反应以及严重烧伤后感染和脓毒症的易感性，我们进行了一项关于急性期反应物和介质的前瞻性、单中心纵向研究。经我院伦理委员会批准，我们在24例患者热损伤后28天的时间内，于入院时及之后每3天检测血浆中IL-2、-6、-8、-10和-13、可溶性IL-2受体（sIL-2R）以及急性期蛋白降钙素原（PCT）和C反应蛋白（CRP）的浓度，并根据烧伤百分比进行分类：≤30%（第1组；n = 12）和>30%（第2组；n = 12）。烧伤后不久，我们发现烧伤面积>30%体表面积的患者中IL-2、-6、-10和PCT浓度较高。在研究期间，我们发现烧伤面积>30%体表面积的患者急性期蛋白、IL-6和-8水平显著更高。烧伤面积>30%体表面积的患者全身炎症反应综合征（SIRS）和多器官功能障碍综合征（MODS）的发生率增加了两倍。我们的结果显示，在较长时间内，不同烧伤面积患者的细胞因子和急性期蛋白模式不同，并且持续监测了这些患者更明显的炎症反应。
