Bakhanashvili T A, Blinkova N F, Maĭsov N I
Biull Eksp Biol Med. 1979 Mar;87(3):237-9.
Dophamine-H3 uptake by synaptosomes and glial cells of the cerebral cortex in rabbits and by the synaptosomes of the cerebral cortex in rats was studied. KM value of the dophamine-H3 uptake was found to be the same (0.075 +/- +/- 0.01 micrometer) in case of synaptosomes and glial cells. The rate of dophamine-H3 uptake by the rabbit cerebral cortex synaptosomes was twice that of the gial cells (as compared by protein). Among the psychotropic agents studied the most active symaptosome uptake inhibitors were phenamine and cocaine; they were less active in respect to glial uptake. Both types of uptake were inhibited by neuroleptics and antidepressants to the same degree. Results of this work conformed to the view on the participation of the strial dophaminergic link in the action mechanism of psychostimulants.
研究了家兔大脑皮层突触体和胶质细胞以及大鼠大脑皮层突触体对多巴胺 - H3的摄取情况。发现多巴胺 - H3摄取的KM值在突触体和胶质细胞中相同（0.075±0.01微米）。家兔大脑皮层突触体摄取多巴胺 - H3的速率是胶质细胞的两倍（以蛋白质含量比较）。在所研究的精神药物中，最有效的突触体摄取抑制剂是苯丙胺和可卡因；它们对胶质细胞摄取的活性较低。这两种摄取类型都被抗精神病药物和抗抑郁药物以相同程度抑制。这项工作的结果符合关于纹状体多巴胺能环节参与精神兴奋剂作用机制的观点。
