Sergeev P V, Vedernikova N N, Maĭskiĭ A I, Shapoval N V, Volov V A
Biull Eksp Biol Med. 1975 Sep;80(9):43-5.
The action of estradiol dipropionate (250 microgram/kg) and of phenobarbitone-sodium salt (80 microgram/kg) was studied in separate and combined (a single injection of estradiol-dipropionate after a 4-day administration of the phenobarbital-sodium salt) administration. There was an increase in the H3-phenylalanine incorporation into the cell-free protein-synthesizing system by 86% in comparison with control ovariectomized group. Under these conditions estradiol-dipropionate increased the incorporation of the labeled amino acid by 53%. A combined administration of the estrogen and of the barbiturate was not accompanied by the summation of the given effect. There was revealed a correlation between the increase in the rate of the H3-phenylalanine incorporation in vitro and an increase in the content of the cytochrome P-450 in vivo in the microsomes of hepatocytes in separate and combined administration of the preparations. The role of phenobarbitone-sodium salt as an activator of estradiol metabolism in the hepatocytes is discussed.
研究了己酸雌二醇（250微克/千克）和苯巴比妥钠盐（80微克/千克）单独给药及联合给药（在连续4天给予苯巴比妥钠盐后单次注射己酸雌二醇）的作用。与对照去卵巢组相比，无细胞蛋白质合成系统中H3 - 苯丙氨酸掺入量增加了86%。在这些条件下，己酸雌二醇使标记氨基酸的掺入量增加了53%。雌激素和巴比妥酸盐联合给药并未使上述效应相加。在单独和联合给药制剂的情况下，体外H3 - 苯丙氨酸掺入速率的增加与体内肝细胞微粒体中细胞色素P - 450含量的增加之间存在相关性。讨论了苯巴比妥钠盐作为肝细胞中雌二醇代谢激活剂的作用。
