Cimarelli A, Darlix J L
U412, Laborétro, Ecole Normale Supérieure de Lyon, France.
Cell Mol Life Sci. 2002 Jul;59(7):1166-84. doi: 10.1007/s00018-002-8495-6.
Retroviral assembly proceeds through a series of concerted events that lead to the formation and release of infectious virion particles from the infected cell. Upon translation, structural proteins are targeted to the plasma membrane where they accumulate. There, the nascent particle forces the plasma membrane to form a bud, which pinches off releasing the virion particle from the cell. In this review we describe the molecular mechanisms now known to be behind the process of virion assembly. In particular, we focus on the human immunodeficiency virus type 1, the prototype member of the lentivirus subfamily of the Retroviridae.
逆转录病毒的组装通过一系列协同事件进行，这些事件导致感染性病毒粒子从受感染细胞中形成并释放。翻译后，结构蛋白被靶向运输到质膜并在那里积累。在质膜处，新生的病毒粒子迫使质膜形成一个芽，芽被掐断从而使病毒粒子从细胞中释放出来。在这篇综述中，我们描述了目前已知的病毒粒子组装过程背后的分子机制。特别地，我们聚焦于1型人类免疫缺陷病毒，它是逆转录病毒科慢病毒亚科的原型成员。
