Johnson D D, McNeill J R, Crawford R D, Wilcox W C
Can J Physiol Pharmacol. 1975 Dec;53(6):1007-13. doi: 10.1139/y75-140.
The anticonvulsant activity of delta9-tetrahydrocannabinol (delta9-THC) has been determined against seizures induced in epileptic chickens by intermittent photic stimulation (IPS) and in epileptic and nonepileptic chickens by Metrazol. Intravenous administration of the drug reduced both the severity and incidence of seizures evoked by IPS in epileptic chickens. This anticonvulsant action was accompanied by a reduction in frequency of inter-ictal slow-wave high-voltage electroencephalographic activity and by the absence of spiking during IPS. delta9-THC did not affect the incidence of Metrazol-induced seizures in epileptic or nonepileptic chickens.
已确定δ9-四氢大麻酚（δ9-THC）对间歇性光刺激（IPS）诱发的癫痫鸡以及戊四氮诱发的癫痫鸡和非癫痫鸡的惊厥具有抗惊厥活性。静脉注射该药物可降低癫痫鸡中由IPS诱发的惊厥的严重程度和发生率。这种抗惊厥作用伴随着发作间期慢波高电压脑电图活动频率的降低以及IPS期间无尖峰波。δ9-THC对癫痫鸡或非癫痫鸡中戊四氮诱发的惊厥发生率没有影响。
