家禽的癫痫样发作。VI. 血浆苯巴比妥浓度和抗惊厥活性。
Epileptiform seizures in domestic fowl. VI. Plasma phenobarbital concentrations and anticonvulsant activity.
作者信息
Johnson D D, Davis H L, Bailey D G, Crawford R D
出版信息
Can J Physiol Pharmacol. 1977 Aug;55(4):848-54. doi: 10.1139/y77-114.
The relationship between plasma phenobarbital concentrations and anticonvulsant activity was determined against seizures induced in epileptic chickens by intermittent photic stimulation (IPS). Intraperitoneally administered phenobarbital produced a plasma-concentration-dependent reduction in both the incidence and severity of seizures. Complete protection against IPS-induced seizures was observed for a period of 6 h after acute phenobarbital administration during which the mean plasma phenobarbital concentrations were between 16.2 +/- 0.91 and 13.6 +/- 1.0 microgram/lm. Plasma phenobarbital concentrations below 3.6 +/- 0.06 microgram/ml had no measurable effect.
针对间歇性光刺激（IPS）诱发的癫痫鸡的癫痫发作，测定了血浆苯巴比妥浓度与抗惊厥活性之间的关系。腹腔注射苯巴比妥可使癫痫发作的发生率和严重程度呈血浆浓度依赖性降低。急性给予苯巴比妥后6小时内观察到对IPS诱发的癫痫发作有完全保护作用，在此期间，血浆苯巴比妥平均浓度在16.2±0.91至13.6±1.0微克/毫升之间。血浆苯巴比妥浓度低于3.6±0.06微克/毫升没有可测量的影响。
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