Keeler R
Can J Physiol Pharmacol. 1975 Dec;53(6):1193-7. doi: 10.1139/y75-166.
Unanesthetized rats treated with deoxycorticosterone acetate were continuously infused with a maximally effective dose of vasopressin (50 muU/min per 100 g). After a control period of 2 h the animals were subjected to a 2 h period of unilateral stimulation of the carotid baroreceptors. There was a large natriuretic response accompanied by diuresis and a fall in urine osmolality. It was concluded that neither the natriuretic nor the diuretic response could be explained by inhibition of vasopressin secretion. Analysis of kidney tissue indicated that the diuresis was associated with partial dissipation of the inner medullary concentration gradient.
用醋酸脱氧皮质酮处理的未麻醉大鼠持续输注最大有效剂量的血管加压素（每100克50微单位/分钟）。在2小时的对照期后，对动物进行2小时的单侧颈动脉压力感受器刺激。出现了大量利钠反应，伴有利尿和尿渗透压下降。得出的结论是，利钠反应和利尿反应均不能用血管加压素分泌受抑制来解释。肾组织分析表明，利尿与髓质内浓度梯度的部分消散有关。
