[大鼠肝前性门静脉高压症的发展]
[Development of pre-hepatic portal hypertension of the rat].
作者信息
Aller Reyero M A, Diéguez Fernández B, Nava Hidalgo M P, Cuesta Alvaro P, Sánchez García M, Duran Giménez-Rico H J, Llamas Matías M A, Arias Pérez J
机构信息
Facultad de Medicina, Universidad Complutense, Pza. Ramón y Cajal s/n, 28040 Madrid.
出版信息
An Med Interna. 2002 Jul;19(7):341-51.
OBJECTIVE
A long-term study of the prehepatic portal hypertension model by triple stenosing ligation of the portal vein in the rat.
METHOD
A cluster analysis of the animals in the different evolutive stages of portal hypertension (1 1/2, 6, 12 and 14 months) has been carried out. This analysis has made it possible to identify three homogeneous groups (A, B and C) in relationship to the liver weight.
RESULTS
The animals with liver atrophy (group C) show a decrease of body, splenic and testicular weights as well as a higher development of the portosystemic collateral circulation in relation to the A and B groups.
CONCLUSION
The percentage of animals belonging to the group C decrease progressively during the evolution of portal hypertension and those animals corresponding to the group A, in which is superior the liver weight, increase, while the B group does not change.
目的
通过大鼠门静脉三重狭窄结扎建立肝前性门静脉高压模型的长期研究。
方法
对门静脉高压不同演变阶段（1.5、6、12和14个月）的动物进行聚类分析。该分析使得能够根据肝脏重量确定三个同质组（A、B和C）。
结果
与A组和B组相比，肝脏萎缩的动物（C组）体重、脾脏重量和睾丸重量下降，门体侧支循环发育更显著。
结论
在门静脉高压演变过程中，属于C组的动物百分比逐渐下降，而肝脏重量较高的A组动物数量增加，B组则无变化。
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