Bakshtanovskaia I V, Stepanova T F, Shonin A L, Terekhina V K, Ponomareva O V
Med Parazitol (Mosk). 2002 Jan-Mar(1):12-6.
The main biochemical indices of hepatic functions (the activities of alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, alkaline phosphatase, alpha-amylase, choline esterase and the concentrations of total bilirubin, cholesterol, and glucose) were studied in the sera of 256 patients with chronic opisthorchiasis. It was found that with diseases manifested in different clinical forms (cholangitis, cholecystitis, cholangiocholecystitis, cholangiohepatitis, cholecystitis in combination with pancreatitis), most study indices are within the normal ranges, but significantly differ from the means in a group of apparently healthy individuals. The findings suggest that such clinical forms of opisthorchiais as cholangiocholecystitis and cholangiohepatitis are characterized by manifestations of cytolysis and cholestasis, as cholecystitis is manifested by cytolysis, as cholecystitis in combination with pancreatitis, by cholestasis, and as cholangitis, by cholestasis and hepatic cell insufficiency. It is possible that further studies will provide evidence for how to correct detected disorders during pathogenetic therapy.
对256例慢性后睾吸虫病患者血清中的肝功能主要生化指标（丙氨酸转氨酶、天冬氨酸转氨酶、γ-谷氨酰转移酶、碱性磷酸酶、α-淀粉酶、胆碱酯酶活性以及总胆红素、胆固醇和葡萄糖浓度）进行了研究。结果发现，在表现为不同临床形式（胆管炎、胆囊炎、胆管胆囊炎、胆管肝炎、胆囊炎合并胰腺炎）的疾病中，大多数研究指标在正常范围内，但与一组明显健康个体的均值有显著差异。研究结果表明，胆管胆囊炎和胆管肝炎等后睾吸虫病临床形式的特征为细胞溶解和胆汁淤积表现，胆囊炎以细胞溶解为表现，胆囊炎合并胰腺炎以胆汁淤积为表现，胆管炎以胆汁淤积和肝细胞功能不全为表现。进一步的研究有可能为在病因治疗期间如何纠正检测到的紊乱提供证据。
