Iakovleva V V, Stepanova T F, Sozonova T A, Rybakova M V, Parfenova G V
Med Parazitol (Mosk). 2002 Jan-Mar(1):19-21.
The higher absorptivity of neutrophils during their alpha-tocopherol stimulation has been found to promote lower adaptability in the metacercariae of Opisthorchis felineus, a reverse picture was observed when cyclophosphanum was used. The antihelminthic effect of biltricide is probably to be unassociated with the changed functional activity of polymorphonuclear leukocytes, but to be determined by its direct action on helminths. This phenomenon was studied on golden hamsters inoculated with Opisthorchis felineus. On day 2 after inoculation, the following drugs were given for a fortnight: biltricide in a single dose of 60 mg/kg weight; biltricide used in a daily fractionated dose of 60 mg/kg; cyclophosphanum (6 mg/kg, every second day); alpha-tocopherol in a daily dose of 30 mg every day.
已发现中性粒细胞在α-生育酚刺激期间的较高吸收率会促使猫后睾吸虫囊蚴的适应性降低，而使用环磷酰胺时则观察到相反的情况。吡喹酮的抗蠕虫作用可能与多形核白细胞功能活性的改变无关，而是由其对蠕虫的直接作用决定。在接种了猫后睾吸虫的金黄仓鼠上研究了这一现象。接种后第2天，给予以下药物两周：单剂量60毫克/千克体重的吡喹酮；每日分次剂量60毫克/千克的吡喹酮；环磷酰胺（6毫克/千克，隔日一次）；每日剂量30毫克的α-生育酚。
