Gutermann A, Bubeck A, Wagner M, Reusch U, Ménard C, Koszinowski U H
Max-von-Pettenkofer Institut, Ludwig-Maximilians-Universität München, 80336 München, Germany.
Curr Top Microbiol Immunol. 2002;269:1-22. doi: 10.1007/978-3-642-59421-2_1.
Co-evolution of herpesviruses with their hosts has resulted in multiple interactions between viral genes and cellular functions. Some interactions control genomic maintenance and replication in specific tissues, other affect the immune control at various stages. Few immunomodulatory functions of genes can be predicted by sequence homology. The majority of genes with immunomodulatory properties only become apparent in functional assays. This chapter reviews procedures which have been used for successful identification of immunomodulatory genes in the past and deals with recent methods which may be applicable for the identification of additional immunomodulatory functions unknown so far.
疱疹病毒与其宿主的共同进化导致了病毒基因与细胞功能之间的多种相互作用。一些相互作用控制特定组织中的基因组维持和复制，另一些则在不同阶段影响免疫控制。通过序列同源性几乎无法预测基因的免疫调节功能。大多数具有免疫调节特性的基因只有在功能试验中才会显现出来。本章回顾了过去用于成功鉴定免疫调节基因的方法，并探讨了可能适用于鉴定迄今未知的其他免疫调节功能的最新方法。
