Guidi-Rontani C, Mock M
Unité Toxines et Pathogénie Bactériennes, CNRS URA 2172, Institut Pasteur, 28 rue du Dr. Roux, 75015 Paris, France.
Curr Top Microbiol Immunol. 2002;271:115-41. doi: 10.1007/978-3-662-05767-4_6.
B. anthracis virulence is the sum of the contributions of factors involved in toxicity, growth and persistence in the host. Recent data has revealed that the interactions between B. anthracis and macrophage is central to the B. anthracis pathogenesis. This review presents and describes tactics by which B. anthracis not only overcomes and avoids macrophages but also perverts the host defense immune system and defense-related products to its advantage. The understanding of the complex network of such interactions is likely to allow new therapeutic and preventative strategies to be developed.
炭疽杆菌的毒力是参与毒性、在宿主体内生长和存活的各种因素作用的总和。最近的数据表明，炭疽杆菌与巨噬细胞之间的相互作用是炭疽杆菌发病机制的核心。本综述介绍并描述了炭疽杆菌不仅克服和逃避巨噬细胞，而且还将宿主防御免疫系统及与防御相关的产物为其所用的策略。对这种相互作用复杂网络的了解可能有助于开发新的治疗和预防策略。
