Sheikh Aleemuzzaman, Sugitani Masahiko, Kinukawa Noriko, Moriyama Mitsuhiko, Arakawa Yasuyuki, Komiyama Kazuo, Li Tian-Cheng, Takeda Naokazu, Ishaque Shamsuddin M, Hasan Mahmud, Suzuki Koyu
Department of Pathology, Nihon University School of Medicine, Tokyo, Japan.
Am J Trop Med Hyg. 2002 Jun;66(6):721-4. doi: 10.4269/ajtmh.2002.66.721.
This is the first study comparing hepatitis E virus (HEV) infection in Bangladesh in fulminant hepatitis (FH) patients presumed to have a viral cause and in the apparently healthy population. Sera from 22 FH patients were analyzed for antibodies to hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C and D viruses, and HEV and for hepatitis B surface antigen (HBsAg). Anti-HEV immunoglobulin M (IgM) was detected in the sera of 63.6% of patients, whereas 35.7% were positive for HBsAg. A high prevalence of HEV infection (83.3%) was noted in the HBV carriers. Serum samples from 273 apparently healthy individuals were tested for antibodies to HAV and HEV. Anti-HEV IgM was detected in 7.3% of the samples. The seroprevalence of HAV differed from that of HEV in the same population because all samples were negative for anti-HAV IgM. These data indicate that HEV infection is highly endemic in Bangladesh.
这是第一项比较孟加拉国暴发性肝炎（FH）患者（推测由病毒引起）和明显健康人群中戊型肝炎病毒（HEV）感染情况的研究。对22例FH患者的血清进行了甲型肝炎病毒（HAV）、乙型肝炎病毒（HBV）、丙型和丁型肝炎病毒以及HEV抗体检测，并检测了乙型肝炎表面抗原（HBsAg）。63.6%的患者血清中检测到抗HEV免疫球蛋白M（IgM），而35.7%的患者HBsAg呈阳性。在HBV携带者中发现HEV感染的患病率很高（83.3%）。对273名明显健康个体的血清样本进行了HAV和HEV抗体检测。7.3%的样本中检测到抗HEV IgM。同一人群中HAV的血清阳性率与HEV不同，因为所有样本的抗HAV IgM均为阴性。这些数据表明HEV感染在孟加拉国高度流行。
