为对氟西汀无反应的强迫症患者添加认知行为疗法。

Addition of cognitive-behaviour therapy for obsessive-compulsive disorder patients non-responding to fluoxetine.

作者信息

Kampman M, Keijsers G P J, Hoogduin C A L, Verbraak M J P M

机构信息

Department of Clinical Psychology, University of Nijmegen and Anxiety Disorders Outpatient Clinic, Nijmegen, The Netherlands.

出版信息

Acta Psychiatr Scand. 2002 Oct;106(4):314-9. doi: 10.1034/j.1600-0447.2002.01261.x.

DOI:10.1034/j.1600-0447.2002.01261.x

PMID:12225499

Abstract

OBJECTIVE

Selective serotonin re-uptake inhibitors (SSRIs) and cognitive behaviour therapy (CBT) have both proven to be effective in the treatment of obsessive compulsive disorder (OCD). It is generally recommended that adequate but unsuccessful SSRI treatment is supplemented with CBT, although only one empirical study was conducted to verify this recommendation. The present study examined the effects of supplemental CBT to continued fluoxetine treatment in OCD patients non-responding to fluoxetine alone.

METHOD

After 12 weeks of fluoxetine, 14 of 56 out-patients had a reduction rate less than 25% on the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and were classified as non-responders. They subsequently received 12 sessions CBT additional to the continued fluoxetine treatment.

RESULTS

The mean symptom reduction as rated by the Y-BOCS, for the patients who completed both treatment phases, was 8.5% in the first phase and 41% in the second phase.

CONCLUSION

Supplemental CBT for OCD patients, after initial, unsuccessful fluoxetine treatment is shown to be effective.

摘要

目的

选择性5-羟色胺再摄取抑制剂（SSRIs）和认知行为疗法（CBT）均已被证明在强迫症（OCD）治疗中有效。一般建议，在选择性5-羟色胺再摄取抑制剂治疗不足或无效时辅以认知行为疗法，不过仅有一项实证研究对这一建议进行了验证。本研究探讨了对单用氟西汀无效的强迫症患者在持续使用氟西汀治疗时辅以认知行为疗法的效果。