Kumaradas J C, Sherar M D
Department of Medical Biophysics, University of Toronto and the Ontario Cancer Institute/Princess Margaret Hospital, Toronto, Ontario, Canada.
Int J Hyperthermia. 2002 Sep-Oct;18(5):441-53. doi: 10.1080/02656730210139609.
Heating of superficial tumours with microwave waveguide applicators has been shown in phase III trials to significantly improve the local control of small lesions when combined with radiation therapy. This success has not yet translated to the treatment of larger tumours, due to difficulty in adequately heating the entire tumour region. Several modifications to the water bolus used with external waveguide applicators have been made in the past in order to increase the heating area. One such modification consisted of a large, microwave-absorbing patch placed inside the bolus, which flattens out the beam profile produced by the applicator. Using this bolus instead of a conventional one resulted in a 30% increase in the effective heating volume produced by the BSD MA120 applicator. This paper describes an optimization procedure for this bolus design which utilises a new finite element model of microwave heating described in an accompanying paper. The optimization procedure resulted in a further 28% increase in the effective heating volume.
在III期试验中已表明，当与放射治疗联合使用时，用微波波导施源器加热浅表肿瘤可显著改善小病灶的局部控制。由于难以充分加热整个肿瘤区域，这一成功尚未转化为对较大肿瘤的治疗。过去已对外置波导施源器使用的水垫进行了一些改进，以增加加热面积。一种改进是在水垫内部放置一个大型微波吸收贴片，它可使施源器产生的波束轮廓变平。使用这种水垫而非传统水垫，可使BSD MA120施源器产生的有效加热体积增加30%。本文描述了这种水垫设计的优化程序，该程序利用了随附论文中描述的一种新的微波加热有限元模型。优化程序使有效加热体积进一步增加了28%。
