Tsukamoto Tetsuro, Yonese Junji, Ishii Nobuyuki, Maezawa Takuya, Fukui Iwao
Department of Urology, Cancer Institute Hospital.
Hinyokika Kiyo. 2002 Jul;48(7):427-30.
A 35-year-old man who had undergone nephroureterectomy and a single cycle of adjuvant MVAC chemotherapy for the left ureteral cancer was referred our clinic for the treatment of paraaortic lymph node metastases. Following histologic confirmation of transitional cell carcinoma by computed tomography (CT) guided biopsy, we treated him with combination chemotherapy consisting of ifosfamide, 5-fluorouracil, etoposide and cisplatin. After 5 cycles of chemotherapy complete remission was obtained. Six months later, however, metastases recurred in the left supraclavicular and paraaortic lymph nodes. Thus, we treated him with a new combination chemotherapy comprising gemcitabine, etoposide and cisplatin which was approved as a phase I study by the institutional review board. Although he was the first patient enrolled in the study and received the minimum dose of gemcitabine (level 1), complete remission was again achieved. Adjuvant radiotherapy of 40 Gy was given to the metastatic sites. He has been well without evidence of disease for 12 months.
一名35岁男性，因左输尿管癌接受了肾输尿管切除术及单周期辅助MVAC化疗，现因腹主动脉旁淋巴结转移转诊至我院接受治疗。经计算机断层扫描（CT）引导下活检组织学确诊为移行细胞癌后，我们采用异环磷酰胺、5-氟尿嘧啶、依托泊苷和顺铂联合化疗对其进行治疗。化疗5个周期后获得完全缓解。然而，6个月后，左锁骨上和腹主动脉旁淋巴结再次出现转移。因此，我们采用了一种新的联合化疗方案对其进行治疗，该方案包括吉西他滨、依托泊苷和顺铂，已获机构审查委员会批准作为I期研究。尽管他是该研究招募的首例患者且接受了最低剂量的吉西他滨（1级），但再次实现了完全缓解。对转移部位给予40 Gy的辅助放疗。他目前情况良好，12个月来无疾病证据。
