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[吉西他滨和顺铂化疗对晚期上尿路尿路上皮癌的病理完全缓解:一例报告]

[Pathological complete response to gemcitabine and cisplatin chemotherapy for advanced upper tract urothelial carcinoma: a case report].

作者信息

Matsuki Masahiro, Takahashi Atsushi, Katou Shuuichi, Takayanagi Akio, Takagi Yoshio, Kamata Kimio

机构信息

Department of Urology, Hakodate Goryoukaku Hospital.

出版信息

Nihon Hinyokika Gakkai Zasshi. 2013 Jan;104(1):33-7. doi: 10.5980/jpnjurol.104.33.

DOI:10.5980/jpnjurol.104.33
PMID:23457933
Abstract

A 61-year-old man was referred to our hospital with the chief complaint of right leg weakness. Abdominal magnetic resonance imaging (MRI) and computed tomography (CT) demonstrated a ureteral tumor and a neighboring massive retroperitoneal tumor in addition to retroperitoneal lymph node and right renal metastases. The tumor was diagnosed as upper tract urothelial carcinoma (cT4N1M1) by percutaneous tumor biopsy. As the patient achieved a partial response after three courses of combination chemotherapy with gemcitabine and cisplatin, he received total nephroureterectomy and lymph node dissection. The pathology showed no viable cancer cells, demonstrating a pathological complete response. He remains alive after 26 months with no evidence of disease.

摘要

一名61岁男性因右腿无力为主诉被转诊至我院。腹部磁共振成像(MRI)和计算机断层扫描(CT)显示除腹膜后淋巴结和右肾转移外,还有输尿管肿瘤及相邻的巨大腹膜后肿瘤。经皮肿瘤活检诊断该肿瘤为上尿路尿路上皮癌(cT4N1M1)。由于患者在接受吉西他滨和顺铂联合化疗三个疗程后获得部分缓解,遂接受了全肾输尿管切除术及淋巴结清扫术。病理检查显示无存活癌细胞,证实为病理完全缓解。他在26个月后仍然存活,无疾病证据。

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[Pathological complete response to gemcitabine and cisplatin chemotherapy for advanced upper tract urothelial carcinoma: a case report].[吉西他滨和顺铂化疗对晚期上尿路尿路上皮癌的病理完全缓解:一例报告]
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A case report--The marked response to gemcitabine combined with irinotecan and low-dose cisplatin chemotherapy for advanced gastric cancer with multiple liver metastases.病例报告——吉西他滨联合伊立替康及小剂量顺铂化疗对晚期胃癌伴多发肝转移的显著疗效
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Who needs further evaluations to diagnose upper urinary tract urothelial cancers among patients with abnormal findings by enhanced CT?对于增强CT检查有异常发现的患者,哪些患者需要进一步评估以诊断上尿路尿路上皮癌?
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Low Doses of Cisplatin Induce Gene Alterations, Cell Cycle Arrest, and Apoptosis in Human Promyelocytic Leukemia Cells.
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