Afonne O J, Orisakwe O E, Ofuefule S I, Tsalha S, Obi E, Ilondu N A, Okorie O
Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi, Anambra State, Nigeria.
Acta Pol Pharm. 2002 May-Jun;59(3):177-9.
The effects of sodium chloride and sodium citrate on the in vitro adsorption of doxycycline to activated charcoal have been studied. Solutions of doxycycline alone and doxycycline with 7.5 mg/ml cathartic solutions were vortex-mixed for 30 s with different quantities of activated charcoal, incubated for 30 min at 37 degrees C and analyzed for free doxycycline spectrophotometrically at 348 nm. Addition of NaCl had a significant (p<0.05) increase while sodium citrate produced a significant (p<0.05) decrease in the adsorption of doxycycline on activated charcoal. In all, the adsorption doxycycline on activated charcoal obeyed quantity-dependent kinetics.
研究了氯化钠和柠檬酸钠对强力霉素在体外吸附到活性炭上的影响。将单独的强力霉素溶液以及含有7.5毫克/毫升泻药溶液的强力霉素溶液与不同量的活性炭进行涡旋混合30秒，在37℃下孵育30分钟，并在348纳米处用分光光度法分析游离强力霉素。添加氯化钠使强力霉素在活性炭上的吸附显著增加（p<0.05），而柠檬酸钠则使其显著减少（p<0.05）。总体而言，强力霉素在活性炭上的吸附符合量依赖性动力学。
