Terada H, Miyoshi T, Imaki M, Nakamura T, Tanada S
Department of Public Health, School of Medicine, University of Tokushima, Japan.
Tokushima J Exp Med. 1994 Jun;41(1-2):31-40.
The adsorption characteristics of paraquat and diquat onto activated carbon in vitro were discussed for the primary treatment of acute poisoning by accidental, suicidal or homicidal ingestion of paraquat containing herbicides. Paraquat was adsorbed onto activated carbon more abundantly and more rapidly in physiological saline solution than that in artificial gastric juice and distilled water. Most suitable solvent for paraquat removal by activated carbon was physiological saline solution (0.9% sodium chloride solution). No significant correlation was observed between the ability of paraquat removal and the properties of adsorbent. Paraquat was preferentially adsorbed onto activated carbon in the mixed solution. The adsorption abilities by activated carbon (the removal ratio, the amount adsorbed and the adsorption rate) for paraquat were larger than those for diquat, and it was enhanced by added sodium chloride and added magnesium sulfate. Enhancing effect for adsorption removal was proportional to the saline concentration. As addition of salts into carbon suspension enhanced the adsorption ability, it will contribute to the effective treatment of acute poisoning.
讨论了百草枯和敌草快在体外对活性炭的吸附特性，用于初步治疗因意外、自杀或他杀摄入含百草枯除草剂而导致的急性中毒。与在人工胃液和蒸馏水中相比，百草枯在生理盐溶液中更大量、更快速地吸附到活性炭上。用于通过活性炭去除百草枯的最合适溶剂是生理盐溶液（0.9%氯化钠溶液）。未观察到百草枯去除能力与吸附剂特性之间存在显著相关性。在混合溶液中，百草枯优先吸附到活性炭上。活性炭对百草枯的吸附能力（去除率、吸附量和吸附速率）大于对敌草快的吸附能力，并且添加氯化钠和硫酸镁可增强该吸附能力。吸附去除的增强效果与盐浓度成正比。由于向碳悬浮液中添加盐增强了吸附能力，这将有助于急性中毒的有效治疗。
