绳状枝顶孢PTCC 5282对氢化可的松的微生物转化

Microbial transformation of hydrocortisone by Acremonium strictum PTCC 5282.

作者信息

Faramarzi Mohammad Ali, Yazdi Mojtaba Tabatabaei, Shafiee Abbas, Zarrini Gholamreza

机构信息

Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, 14174, Tehran, Iran.

出版信息

Steroids. 2002 Sep;67(10):869-72. doi: 10.1016/s0039-128x(02)00049-1.

DOI:10.1016/s0039-128x(02)00049-1

PMID:12231122

Abstract

The ability of a genus of cephalosporium-like fungus isolated from soil, Acremonium strictum PTCC 5282, for hydrocortisone biotransformation has been investigated. This potential had not been previously examined. The fermentation yielded 11beta,17beta-dihydroxyandrost-4-en-3-one, 11beta,17alpha,20beta,21-tetrahydroxypregn-4-en-3-one and 21-acetoxy-11beta,17alpha,20-trihydroxypregn-4-en-3-one. Each microbial metabolite was purified and characterized using spectroscopic methods.

摘要

对从土壤中分离出的一种类头孢菌属真菌——曲霉PTCC 5282进行氢化可的松生物转化能力的研究。此前尚未对这种潜力进行过研究。发酵产物为11β,17β-二羟基雄甾-4-烯-3-酮、11β,17α,20β,21-四羟基孕-4-烯-3-酮和21-乙酰氧基-11β,17α,20-三羟基孕-4-烯-3-酮。每种微生物代谢产物均采用光谱方法进行纯化和表征。