白细胞外渗过程中内皮细胞接触的调节

Regulation of endothelial cell contacts during leukocyte extravasation.

作者信息

Vestweber Dietmar

机构信息

Max-Planck-Institute of Vascular Biology, Institute of Cell Biology, ZMBE University of Münster, Von-Esmarch-Strasse 56, D-48149 Muenster, Germany.

出版信息

Curr Opin Cell Biol. 2002 Oct;14(5):587-93. doi: 10.1016/s0955-0674(02)00372-1.

DOI:10.1016/s0955-0674(02)00372-1

PMID:12231354

Abstract

The molecular mechanisms that control the opening and formation of endothelial cell contacts are of central importance for leukocyte extravasation, endothelial permeability and angiogenesis. Progress has been made in identifying novel membrane proteins at endothelial cell contacts as well as novel mechanisms that control interendothelial adhesiveness and transendothelial migration of leukocytes.

摘要

控制内皮细胞连接的开启和形成的分子机制对于白细胞外渗、内皮通透性和血管生成至关重要。在识别内皮细胞连接处的新型膜蛋白以及控制白细胞在内皮间黏附性和跨内皮迁移的新机制方面已取得进展。