Dejana E, Zanetti A, Del Maschio A
Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
Haemostasis. 1996 Oct;26 Suppl 4:210-9. doi: 10.1159/000217301.
Endothelial cell junctions are complex structures formed by transmembrane adhesive molecules linked to a network of cytoplasmic/cytoskeletal proteins. At least four different types of endothelial junctions have been described (tight junctions, gap junctions, adherence junctions and syndesmos or complexus adhaerentes). Leukocytes adhesion to endothelial cells is frequently followed by their extravasation. The mechanisms which regulate the passage of leukocytes through endothelial clefts remain to be clarified. Many indirect data suggest that leukocytes might transfer signals to endothelial cells both through the release of active agents and adhesion to the endothelial cell surface. These signals could induce the disorganization of interendothelial junctions and facilitate leukocyte transmigration.
内皮细胞连接是由跨膜黏附分子与细胞质/细胞骨架蛋白网络相连形成的复杂结构。至少已描述了四种不同类型的内皮细胞连接（紧密连接、缝隙连接、黏附连接和桥粒或黏附复合体）。白细胞黏附于内皮细胞后常随之发生外渗。调节白细胞通过内皮间隙的机制仍有待阐明。许多间接数据表明，白细胞可能通过释放活性剂和黏附于内皮细胞表面这两种方式向内皮细胞传递信号。这些信号可诱导内皮细胞间连接的紊乱并促进白细胞迁移。
