Torre D
J Dermatol Surg. 1975 Jun;1(2):56-8. doi: 10.1111/j.1524-4725.1975.tb00073.x.
There is need for a storable cryogen suitable for use in dermatological cryosurgery as an alternate for the standard nonstorable cryogen now used (liquid nitrogen). Argon gas was tested and found satisfactory, but has not proved to be commercially feasible. Nitrous oxide apparatus is now available but is of limited usefulness. Various freons (fluorinated hydrocarbons) present possibilities for our use. Although they are incapable of producing the degree of cold and depth of penetration attainable with liquid nitrogen apparatus, they can be used to treat the vast majority of lesions now treated by cryosurgery in an office-based dermatological practice. Freons 12, 22 and 13, alone or mixed with other gases, have been tested. Freon 22 seems the most practical for general dermatologic cryosurgery. Although these gases are considered relatively non-toxic, at this time we really do not know their total noxious capabilities.
需要一种可储存的冷冻剂，用于皮肤科冷冻手术，以替代目前使用的标准不可储存冷冻剂（液氮）。对氩气进行了测试，结果令人满意，但尚未证明在商业上可行。氧化亚氮设备现已可用，但用途有限。各种氟利昂（氟代烃）有供我们使用的可能性。尽管它们无法产生液氮设备所能达到的低温程度和穿透深度，但它们可用于治疗目前在门诊皮肤科实践中通过冷冻手术治疗的绝大多数病变。已对氟利昂12、22和13单独或与其他气体混合进行了测试。氟利昂22似乎是一般皮肤科冷冻手术中最实用的。尽管这些气体被认为相对无毒，但此时我们确实不知道它们的全部有害能力。
