Asada Kazuhiro, Chida Kingo
Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine.
Nihon Rinsho. 2002 Sep;60(9):1839-44.
Sarcoidosis is a systemic granulomatous disease that primarily affects the lung and lymphatic systems. Sarcoidosis patients commonly have spontaneous remission and good prognosis. But some patients show chronic, progressive and life-threatening conditions. Determination of prognosis based on the initial clinical presentation is important for the treatment. In this article, we review natural history, prognosis and the factors related prognosis of sarcoidosis patients in Japan. Shadows on chest radiograph were cleared in 76% of patients for 10 years. Approximately 15% of patients had severe organ dysfunction. In 60% of the sarcoidosis autopsy cases, the causes of death were attributed to organ involvement of sarcoidosis. Adverse prognostic factors are advanced age at onset, the presence of symptoms, extrathoracic involvement and treatment of corticosteroids.
结节病是一种主要累及肺和淋巴系统的全身性肉芽肿性疾病。结节病患者通常会自发缓解且预后良好。但有些患者会出现慢性、进行性且危及生命的情况。基于初始临床表现来判定预后对治疗很重要。在本文中，我们回顾了日本结节病患者的自然病程、预后以及与预后相关的因素。胸部X线片上的阴影在76%的患者中10年内消失。约15%的患者出现严重器官功能障碍。在60%的结节病尸检病例中，死亡原因归因于结节病的器官受累。不良预后因素包括发病时年龄较大、有症状、胸外受累以及使用皮质类固醇治疗。
