POEMS综合征的外周血干细胞移植

Peripheral blood stem cell transplantation for POEMS syndrome.

作者信息

Peggs K S, Paneesha S, Kottaridis P D, Chakraverty R K, Tobias G, Reilly M, Mahendra P, Yong K

机构信息

Department of Haematology, University College London Hospitals, UK.

出版信息

Bone Marrow Transplant. 2002 Sep;30(6):401-4. doi: 10.1038/sj.bmt.1703670.

DOI:10.1038/sj.bmt.1703670

PMID:12235526

Abstract

In common with other plasma cell dyscrasias in which a small tumour burden is associated with severe clinical symptoms (notably systemic AL amyloidosis) the possible benefits of dose intensification are yet to be fully explored in POEMS syndrome. One important issue is whether the toxicity of the procedure is significantly increased in this group. We report two cases of POEMS syndrome with solitary asymptomatic bone lesions treated with high-dose melphalan (200 mg/m(2)) and peripheral blood stem cell (PBSC) rescue. In both cases there was minimal peri-transplant morbidity and a subsequent substantial and maintained improvement in the peripheral neuropathy.

摘要

与其他肿瘤负荷较小却伴有严重临床症状的浆细胞异常增生症（尤其是系统性AL淀粉样变性）一样，剂量强化在POEMS综合征中的潜在益处尚未得到充分探索。一个重要问题是，该组患者治疗过程中的毒性是否会显著增加。我们报告了两例POEMS综合征患者，其患有孤立性无症状骨病变，接受了大剂量美法仑（200mg/m²）治疗及外周血干细胞（PBSC）解救。两例患者移植期间的发病率均极低，且随后外周神经病变有显著且持续的改善。