Steck Andreas J, Czaplinski Adam, Renaud Susanne
Department of Neurology, University of Basel, Basel, Switzerland.
Neurotherapeutics. 2008 Oct;5(4):528-34. doi: 10.1016/j.nurt.2008.08.012.
This review focuses on recent data regarding inflammatory demyelinating neuropathies and neuropathies associated with monoclonal gammopathies. We describe both acute and chronic inflammatory neuropathies, and we discuss conditions ranging from mostly cell-mediated to antibody-mediated disorders. These diseases are characterized by proximal and distal sensory motor involvement. Treatments are based on immune-modulation and/or immune-suppression. Work-up sequence and therapeutical modes are discussed in the light of recently published data, with a special interest on new treatment modalities.
本综述聚焦于近期有关炎性脱髓鞘性神经病及与单克隆丙种球蛋白病相关的神经病的数据。我们描述了急性和慢性炎性神经病,并讨论了从主要由细胞介导到抗体介导的各种病症。这些疾病的特征是近端和远端感觉运动受累。治疗基于免疫调节和/或免疫抑制。根据最近发表的数据讨论了检查顺序和治疗方式,特别关注新的治疗模式。