Bläker F
Leber Magen Darm. 1975 Aug;5(4):167-71.
There is no convincing evidence as yet for a key role of immunological processes in the pathogenesis of unspecific colitis. However clinical findings as well as immunological data do support the hypothesis that immune reactions are involved primarily or secondarily in the pathogenesis and the clinical course of ulcerative colitis and granulomatous colitis. In such patients a specific adaptation of humoral and cell-bound immune reactions against antigenic material from the colon and other tissues has been found in peripheral blood, lymphatic tissue and bowel wall. In this context it seems to be especially noteworthy, that lymphocytes taken from patients with colitis lead to disintegration of colon epithelial cells in vitro. This cytotoxic effect of the lymphocytes is lost after colectomy or remission of the disease. Ulcerative and granulomatous colitis do have many clinical and immunological peculiarities in common. This makes one think, that possibly the same noxious factors induce differential local reactions because of different hereditary disposition.
目前尚无令人信服的证据表明免疫过程在非特异性结肠炎的发病机制中起关键作用。然而，临床发现以及免疫学数据确实支持这样一种假说，即免疫反应主要或次要地参与了溃疡性结肠炎和肉芽肿性结肠炎的发病机制及临床病程。在这类患者的外周血、淋巴组织和肠壁中，已发现针对来自结肠和其他组织的抗原物质的体液免疫和细胞结合免疫反应有特异性适应性改变。在这种情况下，特别值得注意的是，取自结肠炎患者的淋巴细胞在体外可导致结肠上皮细胞解体。淋巴细胞的这种细胞毒性作用在结肠切除术后或疾病缓解后消失。溃疡性结肠炎和肉芽肿性结肠炎在临床和免疫学上有许多共同的特点。这使人认为，可能由于不同的遗传倾向，相同的有害因素会引发不同的局部反应。
