感染HIV的腹泻儿童中的肠道微孢子虫病

Intestinal microsporidiosis in HIV-infected children with diarrhea.

作者信息

Wanachiwanawin Darawan, Chokephaibulkit Kulkanya, Lertlaituan Punpob, Ongrotchanakun Jeerawan, Chinabut Pisith, Thakerngpol Kleophant

机构信息

Department of Parasitology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

出版信息

Southeast Asian J Trop Med Public Health. 2002 Jun;33(2):241-5.

PMID:12236420

Abstract

Intestinal microsporidiosis is a common opportunistic disease associated with diarrhea in adult AIDS patients in Thailand; the data regarding this infection in children are scarce. The present study was designed to investigate the prevalence and clinical features of intestinal microsporidiosis in hospitalized HIV-infected and uninfected (free of HIV) children with diarrhea. Of the 95 HIV-infected children and 87 uninfected children, 24 (25.3%) and 13 (14.9%) respectively were diagnosed with intestinal microsporidiosis. Species identification of microsporidia spores, by transmission electron microscopy, demonstrated Enterocytozoon bieneusi in 5 cases. Cryptosporidium parvum was a common coinfective parasite; pneumonia was the most frequent concurrent disease found in children with intestinal microsporidiosis. Malnutrition was commoner in the HIV-infected group (79.2% vs 23.1%; p = 0.003). This study indicates that intestinal microsporidiosis is an important disease in both HIV-infected and uninfected Thai children with diarrhea.

摘要

肠道微孢子虫病是泰国成年艾滋病患者中一种常见的与腹泻相关的机会性疾病；关于儿童这种感染的数据很少。本研究旨在调查住院的感染HIV和未感染HIV（无HIV）的腹泻儿童中肠道微孢子虫病的患病率和临床特征。在95名感染HIV的儿童和87名未感染的儿童中，分别有24名（25.3%）和13名（14.9%）被诊断为肠道微孢子虫病。通过透射电子显微镜对微孢子虫孢子进行物种鉴定，5例显示为微小隐孢子虫。微小隐孢子虫是常见的合并感染寄生虫；肺炎是肠道微孢子虫病患儿中最常见的并发疾病。营养不良在感染HIV的组中更为常见（79.2%对23.1%；p = 0.003）。本研究表明，肠道微孢子虫病在感染HIV和未感染HIV的泰国腹泻儿童中都是一种重要疾病。