内吗啡肽-2调节肿瘤坏死因子-α、白细胞介素-1β、白细胞介素-10和白细胞介素-12的产生，并改变与巨噬细胞固有免疫相关的功能。
Endomorphin-2 modulates productions of TNF-alpha, IL-1beta, IL-10, and IL-12, and alters functions related to innate immune of macrophages.
作者信息
Azuma Yasutaka, Ohura Kiyoshi
机构信息
Department of Pharmacology, Osaka Dental University, Hirakata, Japan.
出版信息
Inflammation. 2002 Oct;26(5):223-32. doi: 10.1023/a:1019766602138.
We evaluate immunological effects of opioid peptide endomorphin-2 on the production of cytokines related to inflammation and Th1/Th2 balance, and functions related to innate immune of rat peritoneal macrophages. Endomorphin-2 inhibited TNF-alpha, IL-10, and IL-12 productions, but potentiated IL-1beta production by macrophages. Moreover, endomorphin-2 potentiated macrophage adhesion to fibronectin, and the expression of adhesion molecule Mac-1 on macrophages. In contrast, endomorphin-2 suppressed phagocytosis of opsonized E. coli by macrophages, without affecting phagocytosis of non-opsonized E. coli. In addition, endomorphin-2 inhibited macrophage chemotaxis, and the production of superoxide anion by macrophages. These results suggest that endomorphin-2 may alter macrophage functions such as cytokine productions and functions related to innate immune.
我们评估了阿片肽内吗啡肽-2对与炎症及Th1/Th2平衡相关的细胞因子产生以及大鼠腹膜巨噬细胞固有免疫相关功能的免疫效应。内吗啡肽-2抑制肿瘤坏死因子-α（TNF-α）、白细胞介素-10（IL-10）和白细胞介素-12（IL-12）的产生，但增强巨噬细胞白细胞介素-1β（IL-1β）的产生。此外，内吗啡肽-2增强巨噬细胞与纤连蛋白的黏附以及巨噬细胞上黏附分子Mac-1的表达。相反，内吗啡肽-2抑制巨噬细胞对调理化大肠杆菌的吞噬作用，但不影响对未调理化大肠杆菌的吞噬作用。此外，内吗啡肽-2抑制巨噬细胞趋化性以及巨噬细胞超氧阴离子的产生。这些结果表明，内吗啡肽-2可能改变巨噬细胞功能，如细胞因子产生及与固有免疫相关的功能。
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