由不同植物抗病基因介导的两种特定病原体识别事件之间的干扰
Interference between Two Specific Pathogen Recognition Events Mediated by Distinct Plant Disease Resistance Genes.
作者信息
Ritter C., Dangl J. L.
机构信息
Max-Delbruck Laboratory, Carl-von-Linne Weg 10, 50829 Cologne, Germany.
出版信息
Plant Cell. 1996 Feb;8(2):251-257. doi: 10.1105/tpc.8.2.251.
Abstract
We demonstrate that the interaction of the avirulence gene avrRpt2 and the cognate resistance gene RPS2 interferes with the interaction of avrRpm1-RPM1 in Arabidopsis. Interference is mediated outside of the bacterial pathogen Pseudomonas syringae, presumably at the level of recognition of avr-dependent signals, yet does not require the wild-type RPS2 product. A numerical excess of P. syringae expressing avrRpm1 can overcome this interference in mixed inoculations. The interference of avrRpt2-RPS2 engagement with RPM1-dependent functions is mirrored by transcriptional activation of genes preferentially expressed during RPM1- or RPS2-mediated disease resistance reactions. This demonstration of interference between two plant disease resistance genes suggests that their products compete for a common element(s) in a signal transduction pathway leading to disease resistance.
摘要
我们证明，无毒基因avrRpt2与同源抗性基因RPS2的相互作用会干扰拟南芥中avrRpm1与RPM1的相互作用。这种干扰是在丁香假单胞菌病原体之外介导的，大概是在avr依赖信号的识别水平上，但不需要野生型RPS2产物。在混合接种中，表达avrRpm1的丁香假单胞菌数量过多可以克服这种干扰。avrRpt2与RPS2结合对RPM1依赖功能的干扰，可通过在RPM1或RPS2介导的抗病反应中优先表达的基因的转录激活来反映。两个植物抗病基因之间存在干扰的这一证明表明，它们的产物在导致抗病性的信号转导途径中竞争一个共同的元件。
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