Bent A F, Kunkel B N, Dahlbeck D, Brown K L, Schmidt R, Giraudat J, Leung J, Staskawicz B J
Department of Plant Biology, University of California, Berkeley 94720.
Science. 1994 Sep 23;265(5180):1856-60. doi: 10.1126/science.8091210.
Plant disease resistance genes function is highly specific pathogen recognition pathways. PRS2 is a resistance gene of Arabidopsis thaliana that confers resistance against Pseudomonas syringae bacteria that express avirulence gene avrRpt2. RPS2 was isolated by the use of a positional cloning strategy. The derived amino acid sequence of RPS2 contains leucine-rich repeat, membrane-spanning, leucine zipper, and P loop domains. The function of the RPS2 gene product in defense signal transduction is postulated to involve nucleotide triphosphate binding and protein-protein interactions and may also involve the reception of an elicitor produced by the avirulent pathogen.
植物抗病基因的功能具有高度特异性的病原体识别途径。RPS2是拟南芥的一个抗病基因，可赋予对表达无毒基因avrRpt2的丁香假单胞菌的抗性。RPS2是通过位置克隆策略分离得到的。RPS2推导的氨基酸序列包含富含亮氨酸重复序列、跨膜结构域、亮氨酸拉链和P环结构域。推测RPS2基因产物在防御信号转导中的功能涉及三磷酸核苷酸结合和蛋白质-蛋白质相互作用，也可能涉及无毒病原体产生的激发子的识别。
