Cecchettin M, Albertini A, Ghielmi S, Signorini C, Orlandini A, Maiorca R
Quad Sclavo Diagn. 1975 Jun;11(2):397-406.
The AA. have applied the diazoxide test for the screening of primary hiperaldosteronism to 22 nephropatic patients suffering from hypertension and with different degrees of renal function. In 22 patients an increase in PRA and aldosterone values always followed the diazoxide infusion. Only one patient, likely suffering from primary aldosteronism, showed no increase in PRA and aldosterone values. The diazoxide infusion had no influence on renal, pancreatic and cardiovascular function. Therefore, this can be considered as a valid test easy to be performed in a short time, also in nephropatic patients who are very sensitive to pharmacological noxae.
作者对22例患有高血压且肾功能程度不同的肾病患者应用二氮嗪试验来筛查原发性醛固酮增多症。在22例患者中，静脉输注二氮嗪后，血浆肾素活性（PRA）和醛固酮值总是升高。只有1例可能患有原发性醛固酮增多症的患者，其PRA和醛固酮值未升高。二氮嗪输注对肾脏、胰腺和心血管功能没有影响。因此，这可以被认为是一种有效的试验，易于在短时间内进行，对于那些对药物毒性非常敏感的肾病患者也适用。
