肽偶联：基于恶唑酮的偶联反应中氮杂冠醚亲核试剂意外的开环反应
Peptide conjugation: unexpected ring opening of azacrown ether nucleophiles in the oxazolone-based coupling.
作者信息
Belostotskii A M, Genizi E, Hassner A
机构信息
Chemistry Department, Bar-Ilan University, Ramat-Gan 52900, Israel.
出版信息
Chem Commun (Camb). 2001 Oct 7(19):1960-1. doi: 10.1039/b106106m.
DOI:10.1039/b106106m
PMID:12240239
Abstract
Unexpected cleavage of the macrocylic ring of secondary azacrown ethers when interacting with the Aib8 (Aib = alpha-aminoisobutyric acid) oxazolone indicates the possibility for a new mechanism of peptide racemization due to transformations of the oxazolones formed from the N-derivatives of alpha-amino acids in peptide synthesis.
摘要
当二级氮杂冠醚与Aib8（Aib = α-氨基异丁酸）恶唑酮相互作用时，大环发生意外裂解，这表明在肽合成中，由于由α-氨基酸的N-衍生物形成的恶唑酮发生转化，可能存在一种新的肽消旋机制。
Zotero 插件