Koller G, Preuss U W, Bottlender M, Wenzel K, Soyka M
Psychiatrische Klinik und Poliklinik, Ludwig-Maximilians-Universität, Nussbaumstr 7, 80336 München, Germany.
Eur Arch Psychiatry Clin Neurosci. 2002 Aug;252(4):155-60. doi: 10.1007/s00406-002-0362-9.
The aim of this study was to assess the potential role of impulsive and aggressive behavior in the pathogenesis of suicide attempts in alcoholics. Impulsive and aggressive behavior as well as a psychiatric comorbidity with depressive conditions and personality disorders have been reported to be significant risk factors for suicide attempts in alcoholics. We hypothesized that alcoholics with a history of violent suicide attempts show an increased level of impulsive and aggressive behavior. Furthermore, the potential influence of concurrent personality disorders and depressive conditions were assessed.
182 detoxified alcohol-dependent subjects were enrolled into the study. Impulsive and aggressive traits were assessed using the Buss-Durkee Hostility Inventory and the Brown-Goodwin Assessment for Lifetime History of Aggression, personality disorders using the SCID II. Characteristics of alcohol dependence and suicide attempts were evaluated using the Semi-Structured Assessment on Genetics in Alcoholism (SSAGA).
Alcohol-dependent subjects with a history of suicidal behavior show a profile with higher impulsive and aggressive behavior. No significant association between these traits and concurrent borderline and antisocial personality disorder was found. Subjects with suicide attempts tended to have a significantly higher rate of depressive disorders.
These results suggest that impulsive and aggressive traits might contribute significantly to the risk of suicide attempts in alcoholics.
本研究旨在评估冲动和攻击行为在酗酒者自杀未遂发病机制中的潜在作用。据报道，冲动和攻击行为以及与抑郁状况和人格障碍的精神共病是酗酒者自杀未遂的重要危险因素。我们假设，有暴力自杀未遂史的酗酒者表现出更高水平的冲动和攻击行为。此外，还评估了并发人格障碍和抑郁状况的潜在影响。
182名已戒酒的酒精依赖受试者被纳入研究。使用布斯-杜克敌意量表和布朗-古德温攻击行为终身史评估来评估冲动和攻击特质，使用SCID II评估人格障碍。使用酒精中毒遗传学半结构化评估（SSAGA）评估酒精依赖和自杀未遂的特征。
有自杀行为史的酒精依赖受试者表现出更高的冲动和攻击行为特征。未发现这些特质与并发的边缘型和反社会人格障碍之间存在显著关联。有自杀未遂的受试者患抑郁症的比率往往显著更高。
这些结果表明，冲动和攻击特质可能在酗酒者自杀未遂风险中起重要作用。
