Barr Peter B, Neale Zoe, Chatzinakos Chris, Schulman Jessica, Mullins Niamh, Zhang Jian, Chorlian David B, Kamarajan Chella, Kinreich Sivan, Pandey Ashwini K, Pandey Gayathri, Saenz de Viteri Stacey, Acion Laura, Bauer Lance, Bucholz Kathleen K, Chan Grace, Dick Danielle M, Edenberg Howard J, Foroud Tatiana, Goate Alison, Hesselbrock Victor, Johnson Emma C, Kramer John R, Lai Dongbing, Plawecki Martin H, Salvatore Jessica, Wetherill Leah, Agrawal Arpana, Porjesz Bernice, Meyers Jacquelyn L
Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.
VA New York Harbor Healthcare System, Brooklyn, NY, USA.
Complex Psychiatry. 2025 Feb 13;11(1):1-11. doi: 10.1159/000543222. eCollection 2025 Jan-Dec.
Research has identified multiple risk factors associated with suicide attempt (SA) among individuals with psychiatric illness. However, there is limited research among those with an alcohol use disorder (AUD), despite their disproportionately higher rates of SA.
We examined lifetime SA in 4,068 individuals with an AUD from the Collaborative Study on the Genetics of Alcoholism (23% lifetime SA; 53% female; mean age: 38). We explored risk for lifetime SA across other clinical conditions ascertained from a clinical interview, polygenic scores for comorbid psychiatric problems, and neurocognitive functioning.
Participants with an AUD who attempted suicide had greater rates of trauma exposure, major depressive disorder, post-traumatic stress disorder, other substance use disorders (SUDs), and suicidal ideation. Polygenic scores for SA, depression, and PTSD were associated with increased odds of reporting an SA (ORs = 1.22-1.44). Participants who reported an SA also had decreased right hemispheric frontal-parietal theta and decreased interhemispheric temporal-parietal alpha electroencephalogram resting-state coherences relative to those who did not, but differences were small.
Overall, individuals with an AUD who report lifetime SA experience greater levels of trauma, have more severe comorbidities, and carry increased polygenic risk for other psychiatric problems. Our results demonstrate the need to further investigate SAs in the presence of SUDs.
研究已确定了与精神疾病患者自杀未遂（SA）相关的多种风险因素。然而，对于患有酒精使用障碍（AUD）的人群，尽管他们的自杀未遂率高得不成比例，但相关研究却很有限。
我们对来自酒精中毒遗传学合作研究的4068名患有酒精使用障碍的个体进行了终生自杀未遂情况调查（终生自杀未遂率为23%；女性占53%；平均年龄：38岁）。我们探讨了在通过临床访谈确定的其他临床状况、共病精神问题的多基因评分以及神经认知功能方面的终生自杀未遂风险。
有自杀未遂经历的酒精使用障碍参与者遭受创伤、患重度抑郁症、创伤后应激障碍、其他物质使用障碍（SUDs）和自杀意念的比例更高。自杀未遂、抑郁和创伤后应激障碍的多基因评分与报告自杀未遂的几率增加相关（比值比=1.22 - 1.44）。与未报告自杀未遂的参与者相比，报告有自杀未遂经历的参与者右半球额顶叶θ波减少，半球间颞顶叶α波静息态相干性降低，但差异较小。
总体而言，报告有终生自杀未遂经历的酒精使用障碍个体遭受的创伤程度更高，共病情况更严重，且其他精神问题的多基因风险增加。我们的研究结果表明，需要在存在物质使用障碍的情况下进一步调查自杀未遂情况。
