Atmaca Murad, Kuloglu Murat, Tezcan Ertan, Onal Süleyman, Ustundag Bilal
Firat (Euphrates) Universitesi, Firat Tip Merkezi, Psikiyatri Anabilim Dali, 23119 Elazig, Turkey.
Eur Arch Psychiatry Clin Neurosci. 2002 Aug;252(4):161-5. doi: 10.1007/s00406-002-0374-5.
Neopterin has recently gained growing importance as an immunological marker in psychiatric disorders. In the present study, we aimed to evaluate whether the dexamethasone suppression test (DST) and neopterin were associated with posttraumatic stress disorder (PTSD). Fourteen patients with PTSD and 14 controls were enrolled in the study. A clinical evaluation and measurements of cortisol and neopterin levels before and after DST were performed. Additionally, all patients were assessed by Clinician Administered PTSD Scale (CAPS). There was a significantly higher DST nonsuppression in the patient group than control group. There were positive correlations between the duration of illness and CAPS, basal cortisol or postdexamethasone cortisol levels in the patient group. The mean neopterin levels for both before and after DST were significantly lower in the patient group than control group. In conclusion, our results suggest that not only the patients with PTSD have considerable DST nonsuppression but also PTSD may be associated with neopterin.
最近，蝶呤作为精神疾病的一种免疫标志物，其重要性日益凸显。在本研究中，我们旨在评估地塞米松抑制试验（DST）和蝶呤是否与创伤后应激障碍（PTSD）相关。14例PTSD患者和14名对照者纳入本研究。进行了临床评估以及DST前后皮质醇和蝶呤水平的测量。此外，所有患者均通过临床医生用PTSD量表（CAPS）进行评估。患者组DST不抑制情况显著高于对照组。患者组中，病程与CAPS、基础皮质醇或地塞米松后皮质醇水平之间存在正相关。患者组DST前后的平均蝶呤水平均显著低于对照组。总之，我们的结果表明，不仅PTSD患者有相当程度的DST不抑制，而且PTSD可能与蝶呤有关。
