巴拉圭安盖特美洲印第安人群体中MIC无效单倍型（HLA - B48 - MICA - del - MICB*0107 N）的高频率。
High frequency of MIC null haplotype (HLA-B48-MICA-del-MICB*0107 N) in the Angaite Amerindian community in Paraguay.
作者信息
Aida Kayano, Russomando Graciela, Kikuchi Mihoko, Candia Norma, Franco Leticia, Almiron Maria, Ubalee Ratawan, Hirayama Kenji
机构信息
Department of Medical Zoology, Saitama Medical School, Moroyama, Japan.
出版信息
Immunogenetics. 2002 Sep;54(6):439-41. doi: 10.1007/s00251-002-0485-1. Epub 2002 Jul 16.
We describe a high frequency of the MIC null haplotype, HLA-B48-MICA-del-MICB0107 N, in the Angaite Amerindian community in Paraguay. Of the 16 unrelated subjects, 9 (56.5%) had this haplotype. The structural analyses revealed this haplotype was similar to the previously reported Asian haplotype in that they had a large-scale deletion including the entire MICA gene and linked to MICB0107 N and HLA-B48. The novel recombination haplotype between this MIC null haplotype and HLA-B15, HLA-B15-MICA-del-MICB0107 N, was also found in this community.
我们描述了在巴拉圭的安盖特美洲印第安人群体中，MIC无效单倍型HLA - B48 - MICA - del - MICB0107 N的高频率出现情况。在16名无亲缘关系的个体中，9名（56.5%）拥有这种单倍型。结构分析表明，这种单倍型与先前报道的亚洲单倍型相似，即它们都有一个包括整个MICA基因的大规模缺失，并且与MICB0107 N和HLA - B48相关联。在该群体中还发现了这种MIC无效单倍型与HLA - B15之间的新型重组单倍型，即HLA - B15 - MICA - del - MICB0107 N。
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