Aida Kayano, Russomando Graciela, Kikuchi Mihoko, Candia Norma, Franco Leticia, Almiron Maria, Ubalee Ratawan, Hirayama Kenji
Department of Medical Zoology, Saitama Medical School, Moroyama, Japan.
Immunogenetics. 2002 Sep;54(6):439-41. doi: 10.1007/s00251-002-0485-1. Epub 2002 Jul 16.
We describe a high frequency of the MIC null haplotype, HLA-B48-MICA-del-MICB0107 N, in the Angaite Amerindian community in Paraguay. Of the 16 unrelated subjects, 9 (56.5%) had this haplotype. The structural analyses revealed this haplotype was similar to the previously reported Asian haplotype in that they had a large-scale deletion including the entire MICA gene and linked to MICB0107 N and HLA-B48. The novel recombination haplotype between this MIC null haplotype and HLA-B15, HLA-B15-MICA-del-MICB0107 N, was also found in this community.
我们描述了在巴拉圭的安盖特美洲印第安人群体中，MIC无效单倍型HLA - B48 - MICA - del - MICB0107 N的高频率出现情况。在16名无亲缘关系的个体中，9名（56.5%）拥有这种单倍型。结构分析表明，这种单倍型与先前报道的亚洲单倍型相似，即它们都有一个包括整个MICA基因的大规模缺失，并且与MICB0107 N和HLA - B48相关联。在该群体中还发现了这种MIC无效单倍型与HLA - B15之间的新型重组单倍型，即HLA - B15 - MICA - del - MICB0107 N。
