Sari Ramazan, Yildirim Bulent, Sevinc Alper, Bahceci Funda, Hilmioglu Fatih
Department of Internal Medicine, Inonu University, School of Medicine, Turgut Ozal Medical Center, TR-44069 Malatya, Turkey.
J Clin Ultrasound. 2002 Oct;30(8):477-80. doi: 10.1002/jcu.10108.
The aim of this study was to evaluate differences in gallbladder contractility by measuring gallbladder wall thickness, fasting and residual gallbladder volume, and gallbladder ejection fraction in patients with cirrhotic and malignant ascites.
Twenty-four patients (16 women and 8 men) with malignant ascites (2 cervical, 2 colon, 2 stomach, 6 pancreatic, and 12 ovarian carcinomas), aged 59 +/- 12 years, and 26 patients (14 women and 12 men) with cirrhotic ascites, aged 57 +/- 16 years, were included in the study. After patients fasted overnight for 8 hours, gallbladder wall thickness, fasting gallbladder volume, and gallbladder volume and ejection fraction were measured sonographically at 10, 20, 30, 40, 50, 60, 70, 80, and 90 minutes after ingestion of a standard liquid test meal.
The mean gallbladder wall thickness was higher in patients with cirrhotic ascites than in those with malignant ascites (5.5 +/- 1.5 mm [standard deviation] versus 3.1 +/- 0.6 mm, respectively; p < 0.001). The mean fasting gallbladder volume was also higher in patients with cirrhotic ascites than in those with malignant ascites (27.3 +/- 11.5 cm(3) versus 17.6 +/- 8.9 cm(3); p < 0.05). Patients with cirrhotic ascites had significantly higher mean postprandial gallbladder volumes and ejection fractions than did those with malignant ascites at all times except 10 minutes after the meal (p < 0.05).
Our findings suggest that gallbladder contractility is greater in patients with cirrhotic ascites than in patients with malignant ascites.
本研究旨在通过测量肝硬化腹水和恶性腹水患者的胆囊壁厚度、空腹及残余胆囊体积以及胆囊排空分数，评估胆囊收缩性的差异。
本研究纳入了24例恶性腹水患者（16例女性，8例男性），年龄59±12岁（2例宫颈癌、2例结肠癌、2例胃癌、6例胰腺癌和12例卵巢癌），以及26例肝硬化腹水患者（14例女性，12例男性），年龄57±16岁。患者夜间禁食8小时后，在摄入标准液体试验餐后10、20、30、40、50、60、70、80和90分钟，通过超声测量胆囊壁厚度、空腹胆囊体积、胆囊体积及排空分数。
肝硬化腹水患者的平均胆囊壁厚度高于恶性腹水患者（分别为5.5±1.5mm[标准差]和3.1±0.6mm；p<0.001）。肝硬化腹水患者的平均空腹胆囊体积也高于恶性腹水患者（27.3±11.5cm³对17.6±8.9cm³；p<0.05）。除餐后10分钟外，肝硬化腹水患者在所有时间点的餐后胆囊平均体积和排空分数均显著高于恶性腹水患者（p<0.05）。
我们的研究结果表明，肝硬化腹水患者的胆囊收缩性大于恶性腹水患者。
