Yakimovskii A F
Laboratory for the Physiology of Higher Nervous Activity, I. P. Pavlov Institute of Physiology, Moscow, Russia.
Neurosci Behav Physiol. 2002 Jul-Aug;32(4):443-7. doi: 10.1023/a:1015844630749.
The effects of chronic administration of phenamine (15 microg) into the neostriatum and bicucculline (5 microg) in the globus pallidus of rats on the performance of avoidance behavior in a shuttle box were studied. Agents were injected daily for three weeks, and control animals received physiological saline. Activation of the dopaminergic system of the neostriatum compensated for decreases in avoidance behavior due to surgical trauma, increased the intensity of spontaneous activity in the "open field," and induced motor stereotypy. Administration of bicucculline into the globus pallidus produced sharp worsening of conditioned reflex avoidance behavior throughout the treatment period (spontaneous movement activity showed no significant change), with recovery only occurring two weeks after the last microinjection. Simultaneous treatment with phenamine into the neostriatum and bicucculline into the globus pallidus resulted in compensation for the inhibitory effects of bicucculline. Several phases were observed in behavioral changes, apparently reflecting the dynamics of interactions between the neo- and paleostriatum. The significance of the coordination of intrastriatal functions for the regulatory activity of the basal ganglia is discussed.
研究了向大鼠新纹状体慢性注射苯丙胺（15微克）和苍白球慢性注射荷包牡丹碱（5微克）对穿梭箱中回避行为表现的影响。药物每日注射，持续三周，对照动物注射生理盐水。新纹状体多巴胺能系统的激活补偿了因手术创伤导致的回避行为减少，增加了“旷场”中自发活动的强度，并诱发了运动刻板行为。向苍白球注射荷包牡丹碱在整个治疗期间使条件反射回避行为急剧恶化（自发运动活动无显著变化），仅在最后一次微量注射两周后才恢复。同时向新纹状体注射苯丙胺和向苍白球注射荷包牡丹碱可补偿荷包牡丹碱的抑制作用。在行为变化中观察到几个阶段，显然反映了新纹状体和苍白球之间相互作用的动态过程。讨论了纹状体内功能协调对基底神经节调节活动的意义。
