Weaver Timothy E, Na Cheng-Lun, Stahlman Mildred
Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA.
Semin Cell Dev Biol. 2002 Aug;13(4):263-70. doi: 10.1016/s1084952102000551.
Lamellar bodies are members of a subclass of lysosome-related organelles referred to as secretory lysosomes. The principal constituents of the lamellar body, surfactant phospholipids, are organized into tightly packed, bilayer membranes in a process that is strongly influenced by the lung-specific, hydrophobic peptide SP-B. Newly synthesized SP-B is transported from the Golgi to the lamellar body via multivesicular bodies; in contrast, preliminary evidence suggests that newly synthesized surfactant phospholipids are transported from the ER and incorporated into the internal membranes of the lamellar body via a distinct pathway.
板层小体是溶酶体相关细胞器亚类的成员，被称为分泌性溶酶体。板层小体的主要成分表面活性物质磷脂，在受肺特异性疏水肽SP-B强烈影响的过程中，被组织成紧密堆积的双层膜。新合成的SP-B通过多囊泡体从高尔基体转运至板层小体；相比之下，初步证据表明新合成的表面活性物质磷脂从内质网转运，并通过一条独特途径掺入板层小体的内膜。
