Fillatreau Simon, Sweenie Claire H, McGeachy Mandy J, Gray David, Anderton Stephen M
University of Edinburgh, Institute of Cell, Animal and Population Biology, King's Buildings West Mains Road, Edinburgh EH9 3JT, UK.
Nat Immunol. 2002 Oct;3(10):944-50. doi: 10.1038/ni833. Epub 2002 Sep 3.
To assess the importance of B cell control of T cell differentiation, we analyzed the course of the T helper type 1 (T(H)1)-driven disease experimental autoimmune encephalomyelitis in mice with an altered B cell compartment. We found that recovery was dependent on the presence of autoantigen-reactive B cells. B cells from recovered mice produced interleukin 10 (IL-10) in response to autoantigen. With a bone marrow chimeric system, we generated mice in which IL-10 deficiency was restricted to B cells but not T cells. In the absence of IL-10 production by B cells, the pro-inflammatory type 1 immune response persisted and mice did not recover. These data show that B cell-derived IL-10 plays a key role in controlling autoimmunity.
为了评估B细胞对T细胞分化的控制作用的重要性，我们分析了B细胞区室改变的小鼠中由1型辅助性T细胞（Th1）驱动的疾病——实验性自身免疫性脑脊髓炎的病程。我们发现恢复依赖于自身抗原反应性B细胞的存在。来自恢复小鼠的B细胞在接触自身抗原后产生白细胞介素10（IL-10）。利用骨髓嵌合系统，我们培育出了IL-10缺陷仅限于B细胞而非T细胞的小鼠。在B细胞不产生IL-10的情况下，促炎性1型免疫反应持续存在，小鼠无法恢复。这些数据表明，B细胞来源的IL-10在控制自身免疫中起关键作用。
