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Investigation of the safe withdrawal period for propranolol in patients scheduled for open heart surgery.接受心脏直视手术患者普萘洛尔安全撤药期的研究。
Br Heart J. 1975 Dec;37(12):1228-34. doi: 10.1136/hrt.37.12.1228.
2
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2
Antiarrhythmic drugs: clinical pharmacology and therapeutic uses.抗心律失常药物：临床药理学与治疗用途
Drugs. 1978 Apr;15(4):271-309. doi: 10.2165/00003495-197815040-00003.
3
Predictors of operative mortality for coronary bypass grafting in patients with ischemic heart disease.缺血性心脏病患者冠状动脉搭桥手术的手术死亡率预测因素。
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本文引用的文献

1
Systolic time intervals in heart failure in man.人类心力衰竭时的收缩期时间间期
Circulation. 1968 Feb;37(2):149-59. doi: 10.1161/01.cir.37.2.149.
2
Plasma propranolol levels in adults with observations in four children.成人血浆普萘洛尔水平及对四名儿童的观察结果
Clin Pharmacol Ther. 1970 Jan-Feb;11(1):112-20. doi: 10.1002/cpt1970111112.
3
Propranolol and cardiac surgery.普萘洛尔与心脏手术
J Thorac Cardiovasc Surg. 1972 Nov;64(5):826-30.
4
The disposition of propranolol. I. Elimination during oral absorption in man.普萘洛尔的处置。I. 人体口服吸收过程中的消除
Pharmacology. 1972;7(3):159-68. doi: 10.1159/000136285.
5
Development of human foetal inotropic responses to catecholamines.
Experientia. 1972 May 15;28(5):525-6. doi: 10.1007/BF01931857.
6
A standardized isoproterenol sensitivity test. The effects of sinus arrhythmia, atropine, and propranolol.一项标准化的异丙肾上腺素敏感性试验。窦性心律失常、阿托品和普萘洛尔的作用。
Arch Intern Med. 1972 Jul;130(1):47-52. doi: 10.1001/archinte.130.1.47.
7
Studies on the absorption, distribution and excretion of propranolol in rat, dog and monkey.大鼠、犬和猴体内普萘洛尔的吸收、分布及排泄研究。
J Pharmacol Exp Ther. 1971 Feb;176(2):302-11.
8
Time required for complete recovery from chronic propranolol therapy.从慢性普萘洛尔治疗中完全恢复所需的时间。
N Engl J Med. 1973 Sep 20;289(12):607-9. doi: 10.1056/NEJM197309202891204.
9
Pharmacology of 4-hydroxypropranolol, a metabolite of propranolol.普萘洛尔的代谢产物4-羟基普萘洛尔的药理学
Br J Pharmacol. 1971 Sep;43(1):222-35. doi: 10.1111/j.1476-5381.1971.tb07171.x.
10
Plasma propranolol levels in the quaniitative assessment of beta-adrenergic blockade in man.人体β-肾上腺素能阻滞定量评估中的血浆普萘洛尔水平
Br Med J. 1970 Sep 26;3(5725):731-4. doi: 10.1136/bmj.3.5725.731.

接受心脏直视手术患者普萘洛尔安全撤药期的研究。

Investigation of the safe withdrawal period for propranolol in patients scheduled for open heart surgery.

作者信息

Coltart D J, Cayen M N, Stinson E B, Goldman R H, Davies R O, Harrison D C

出版信息

Br Heart J. 1975 Dec;37(12):1228-34. doi: 10.1136/hrt.37.12.1228.

DOI:10.1136/hrt.37.12.1228
PMID:1225337
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC482945/
Abstract

The time necessary for dissipation of radioactive labelled propranolol and its metabolites and the cardiac effects of this agent in the hearts of patients undergoing open-heart surgery were studied. Isoprenaline produced chronotropic and inotropic responses in atrial muscle in tissue bath studies which were normal 8 to 12 hours after withdrawing propranolol. After the administration of either 25 or 75 muCi of 14C-labelled propranolol, the myocardial tissue concentration declined to insignificant levels between 24 and 28 hours. We conclude that withdrawal of propranolol therapy 24 to 48 hours before cardiac surgery should be acceptable.

摘要

研究了放射性标记的普萘洛尔及其代谢产物消散所需的时间，以及该药物对接受心脏直视手术患者心脏的影响。在组织浴研究中，异丙肾上腺素在心房肌中产生变时性和变力性反应，在停用普萘洛尔8至12小时后这些反应正常。给予25或75微居里的14C标记普萘洛尔后，心肌组织浓度在24至28小时内降至微不足道的水平。我们得出结论，在心脏手术前24至48小时停用普萘洛尔治疗应该是可以接受的。