接受心脏直视手术患者普萘洛尔安全撤药期的研究。
Investigation of the safe withdrawal period for propranolol in patients scheduled for open heart surgery.
作者信息
Coltart D J, Cayen M N, Stinson E B, Goldman R H, Davies R O, Harrison D C
出版信息
Br Heart J. 1975 Dec;37(12):1228-34. doi: 10.1136/hrt.37.12.1228.
Abstract
The time necessary for dissipation of radioactive labelled propranolol and its metabolites and the cardiac effects of this agent in the hearts of patients undergoing open-heart surgery were studied. Isoprenaline produced chronotropic and inotropic responses in atrial muscle in tissue bath studies which were normal 8 to 12 hours after withdrawing propranolol. After the administration of either 25 or 75 muCi of 14C-labelled propranolol, the myocardial tissue concentration declined to insignificant levels between 24 and 28 hours. We conclude that withdrawal of propranolol therapy 24 to 48 hours before cardiac surgery should be acceptable.
摘要
研究了放射性标记的普萘洛尔及其代谢产物消散所需的时间，以及该药物对接受心脏直视手术患者心脏的影响。在组织浴研究中，异丙肾上腺素在心房肌中产生变时性和变力性反应，在停用普萘洛尔8至12小时后这些反应正常。给予25或75微居里的14C标记普萘洛尔后，心肌组织浓度在24至28小时内降至微不足道的水平。我们得出结论，在心脏手术前24至48小时停用普萘洛尔治疗应该是可以接受的。
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