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[肺在捕获皮下注射抗原中的作用]

[Participation of the lung in capturing subcutaneously injected antigens].

作者信息

Shul'man B B, Karpov V S

出版信息

Biull Eksp Biol Med. 1975 Dec;80(12):56-9.

PMID:1225401
Abstract

Experiments were conducted on guinea pigs. With the aid of fluorescein-labeled antibodies it was shown that following a single or a two-fold immunization into the footpad complete typhoid antigen was revealed in the lung macrophages as soon as the first days (or after a two-fold administration-in several hours) and persisted there for 30 days. There was a tendency to concentration of the antigen-containing macrophages in the perivascular and the peribronchial tissues. The dynamics of the antigen spread along the lymphoid organs is also described.

摘要

在豚鼠身上进行了实验。借助荧光素标记抗体发现,在足垫单次或两次免疫后,最早在第一天(或两次给药后——数小时后)肺巨噬细胞中就出现了完全伤寒抗原,并在那里持续存在30天。含抗原的巨噬细胞有集中在血管周围和支气管周围组织的趋势。还描述了抗原沿淋巴器官扩散的动态过程。

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