Abramets I I, Komissarov I V, Shovtuta V I
Biull Eksp Biol Med. 1975 Dec;80(12):6-8.
In concentrations of 10(-9)-10(-7) g/ml acetylcholine increased the tone of the smooth muscles of the longitudinal band of the large intestine of a guinea pig, increasing the permeability of the cellular membranes for the entering flux of 45Ca2+. In concentrations of 10(-6) g/ml and over acetylcholine caused a release of the membranous calcium and in the concentrations of 10(-5)-10(-3) g/ml markedly increased the permeability of the membranes of the smooth muscle cells for the 22Na+ ions causing depolarization and an increase in the frequency of the action potentials. It is supposed that the coupling of the cholinergic stimulus with the end effect (muscle contraction) included 3 components: intensification of the entrance of Ca2+ into the smooth muscle cells, release of the membrane calcium and adhesion mechanism.
浓度为10⁻⁹ - 10⁻⁷克/毫升时，乙酰胆碱可增强豚鼠大肠纵行肌条平滑肌的张力，增加细胞膜对进入的45Ca²⁺的通透性。浓度为10⁻⁶克/毫升及以上时，乙酰胆碱会导致膜结合钙的释放，而在10⁻⁵ - 10⁻³克/毫升的浓度下，会显著增加平滑肌细胞膜对22Na⁺离子的通透性，引起去极化并增加动作电位的频率。据推测，胆碱能刺激与最终效应（肌肉收缩）的耦合包括三个成分：Ca²⁺进入平滑肌细胞的增强、膜结合钙的释放以及黏附机制。
