[生物活性物质（乙酰胆碱、组胺和缓激肽）对结肠带平滑肌去极化的影响]
[The effect of biologically active substances (acetylcholine, histamine and bradykinin) on depolarization of taenia coli smooth muscle].
作者信息
Pogadaev V I, Timin E N
出版信息
Biull Eksp Biol Med. 1976 Jan;81(1):12-4.
PMID:1247665
Abstract
In experiments on the isolated strips of Taenia coli of guinea pigs it was shown that compound D-600 depressed the acetylcholine (5-10(-6), histamine (2-10(-6) and bradykinin (10(-5) gl/ml)-induced contractile response of depolarized smooth muscle. Along with depression of the drug-induced response, compound D-600 depressed the "potassium contracture". It is supposed that the mentioned agents activated the inward flow of Ca2+ ions through the membrane, but not the release of these ions from the sarcoplasmic reticulum.
摘要
在豚鼠结肠带的离体实验中表明，化合物D - 600可抑制乙酰胆碱（5×10⁻⁶）、组胺（2×10⁻⁶）和缓激肽（10⁻⁵微克/毫升）诱导的去极化平滑肌收缩反应。除抑制药物诱导的反应外，化合物D - 600还抑制“钾挛缩”。据推测，上述药物通过激活Ca²⁺离子内流穿过细胞膜，而非从肌浆网释放这些离子。
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