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The importance of the conformation of the tetrahedral intermediate for the alpha-chymotrypsin-catalyzed hydrolysis of peptide substrates.

作者信息

Bizzozero S A, Zweifel B O

出版信息

FEBS Lett. 1975 Nov 1;59(1):105-8. doi: 10.1016/0014-5793(75)80351-6.

DOI:10.1016/0014-5793(75)80351-6
PMID:1225610
Abstract
摘要

相似文献

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The importance of the conformation of the tetrahedral intermediate for the alpha-chymotrypsin-catalyzed hydrolysis of peptide substrates.四面体中间体的构象对α-胰凝乳蛋白酶催化肽底物水解的重要性。
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2
Effect of pressure on the pre-steady-state kinetics of the hydrolysis of anilide substrates catalyzed by alpha-chymotrypsin.
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[Theoretical aspects of the mechanism of proteolytic enzyme action. V. C-terminal specificity of serine proteinases].[蛋白水解酶作用机制的理论方面。V. 丝氨酸蛋白酶的C端特异性]
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Kinetic studies on the mechanism and the specificity of peptide semisynthesis catalyzed by the serine proteases alpha-chymotrypsin and beta-trypsin.关于丝氨酸蛋白酶α-胰凝乳蛋白酶和β-胰蛋白酶催化的肽半合成机制及特异性的动力学研究。
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Specificity of -chymotrypsin. Separation of polar, steric, and specific effects in the -chymotrypsin-catalyzed hydrolysis of acyl-substituted p-nitrophenyl esters.胰凝乳蛋白酶的特异性。在胰凝乳蛋白酶催化的酰基取代对硝基苯酯水解反应中极性、空间和特异性效应的分离。
Biochemistry. 1973 Jul 3;12(14):2559-66. doi: 10.1021/bi00738a002.

引用本文的文献

1
Current problems in mechanistic studies of serine and cysteine proteinases.丝氨酸蛋白酶和半胱氨酸蛋白酶机制研究中的当前问题。
Biochem J. 1982 Oct 1;207(1):1-10. doi: 10.1042/bj2070001.
2
Refined crystal structure of the molecular complex of Streptomyces griseus protease B, a serine protease, with the third domain of the ovomucoid inhibitor from turkey.灰色链霉菌蛋白酶B（一种丝氨酸蛋白酶）与来自火鸡的卵类粘蛋白抑制剂第三结构域的分子复合物的精细晶体结构。
Proc Natl Acad Sci U S A. 1982 Aug;79(16):4868-72. doi: 10.1073/pnas.79.16.4868.
3
Stereoelectronic control in peptide bond formation. Ab initio calculations and speculations on the mechanism of action of serine proteases.
肽键形成中的立体电子控制。从头算计算以及对丝氨酸蛋白酶作用机制的推测。
Biophys J. 1984 Dec;46(6):749-61. doi: 10.1016/S0006-3495(84)84073-4.
4
Evidence that the lack of high catalytic activity of thiolsubtilisin towards specific substrates may be due to an inappropriately located proton-distribution system. Demonstration of highly nucleophilic character of the thiol group of thiolsubtilisin in the catalytically relevant ionization state of the active centre by use of a two-protonic-state reactivity probe.有证据表明，硫醇枯草杆菌蛋白酶对特定底物缺乏高催化活性可能是由于质子分布系统定位不当。通过使用双质子态反应性探针，证明了在活性中心的催化相关电离状态下硫醇枯草杆菌蛋白酶硫醇基团具有高度亲核性。
Biochem J. 1981 Mar 1;193(3):819-23. doi: 10.1042/bj1930819.
5
Mechanism of the reaction of papain with substrate-derived diazomethyl ketones. Implications for the difference in site specificity of halomethyl ketones for serine proteinases and cysteine proteinases and for stereoelectronic requirements in the papain catalytic mechanism.木瓜蛋白酶与底物衍生的重氮甲基酮的反应机制。对卤甲基酮对丝氨酸蛋白酶和半胱氨酸蛋白酶的位点特异性差异以及木瓜蛋白酶催化机制中的立体电子要求的影响。
Biochem J. 1978 Nov 1;175(2):761-4. doi: 10.1042/bj1750761.
6
Evidence that binding to the s2-subsite of papain may be coupled with catalytically relevant structural change involving the cysteine-25-histidine-159 diad. Kinetics of the reaction of papain with a two-protonic-state reactivity probe containing a hydrophobic side chain.有证据表明，与木瓜蛋白酶的s2亚位点结合可能与涉及半胱氨酸-25-组氨酸-159二元组的催化相关结构变化相关联。木瓜蛋白酶与含有疏水侧链的双质子态反应性探针反应的动力学。
Biochem J. 1979 Nov 1;183(2):223-31. doi: 10.1042/bj1830223.