Middaugh L D, Santos C A, Zemp J W
Dev Psychobiol. 1975 Jul;8(4):305-13. doi: 10.1002/dev.420080404.
Mature offspring of C57BL/6J mice (Mus musculus) injected daily with phenobarbital (40 mg/kg) for the last third of pregnancy differed from saline and untreated control animals on 3 measures of behavior. Offspring of phenobarbital treated animals had higher locomotor scores than controls during an open field activity test at 75 days of age. Male offspring were also tested on a 1-trial passive avoidance task and treated animals were found to be deficient. Finally, female offspring responded less than controls on fixed ratio schedules of reinforcement. The behavioral changes suggest that offspring of mice injected with phenobarbital during pregnancy are less responsive to the stimuli in their environment which maintain behavior.
在妊娠最后三分之一阶段每天注射苯巴比妥（40毫克/千克）的C57BL/6J小鼠（小家鼠）的成熟后代，在三项行为测量指标上与注射生理盐水和未处理的对照动物有所不同。在75日龄的旷场活动测试中，经苯巴比妥处理的动物后代的运动得分高于对照组。雄性后代还接受了一次性被动回避任务测试，结果发现经处理的动物存在缺陷。最后，在固定比率强化程序中，雌性后代的反应比对照组少。这些行为变化表明，孕期注射苯巴比妥的小鼠后代对维持行为的环境刺激反应较弱。
